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3 978 (0,131s) •

Project

Development and characterization of small molecules modulating activity of DNA-PK (GA25-17299S)

Small molecules targeting DNA repair may sensitize tumors to radiotherapy attention has been paid to Ku. The goal of this application is to characterize small molecule inhibitors of Ku identified in the ap...

Biochemistry and molecular biology

  • 2025 - 2027
    • •
  • 10 224 tis. Kč
    • •
  • 10 053 tis. Kč
    • •
  • GA ČR
Project

Targeting oncogenic kinases with small molecules (GA21-06553S)

There are numerous cancer types, which still await selective and targeted drugs. This project is focused on development of novel small molecule inhibitors of protein are potent inhibitors of protein kinases BTK, SY...

Medicinal chemistry

  • 2021 - 2024
    • •
  • 6 487 tis. Kč
    • •
  • 6 487 tis. Kč
    • •
  • GA ČR
Project

Developing a novel Casein Kinase 1 inhibitor for treatment of pancreatic cancer An AI-integrated approach (7D241001)

1/ Best-in-class CK1 inhibitor lead (CI-CK1i) validated in in vitro, in vivo, and in silico models for efficacy in pancreatic cancer (PANC) in various combinations with existing treatments, including standard-of-care gemcitabine, FOLFIRINOX,...

Oncology

  • 2024 - 2027
    • •
  • 19 821 tis. Kč
    • •
  • 11 883 tis. Kč
    • •
  • MŠMT
Project

Development of novel radioprotective agents based on small molecule inhibitors (GA17-13541S)

in this process, its inhibition increases resistance against radiation. Inhibitors of PUMA...

FD - Onkologie a hematologie

  • 2017 - 2019
    • •
  • 9 840 tis. Kč
    • •
  • 9 840 tis. Kč
    • •
  • GA ČR
Project

Development of chemical regulators of miRNA and RNAi pathways (GA13-29531S)

of small molecules inhibiting or stimulating miRNA and RNAi pathways and (2) identify, and other pathways influence the miRNA pathway. Small molecules will make excellent. These pathways use small RNAs as...

EB - Genetika a molekulární biologie

  • 2013 - 2018
    • •
  • 8 056 tis. Kč
    • •
  • 8 056 tis. Kč
    • •
  • GA ČR
Project

Development of novel small molecules anticancer compounds with synthetic lethal effect (NV15-33999A)

The project consists of preclinical development of novel small-molecule selective inhibitor of CHK1 kinase (OH209EN1) with expected effective antitumour activity based on the concept of synthetic lethality. This revolutiona...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 16 815 tis. Kč
    • •
  • 14 821 tis. Kč
    • •
  • MZ
Project

Parasite-targeted peptidase inhibitors as a tool for schistosomiasis therapy. (GA203/09/1585)

will provide novel small-molecule structures as leads for the development on design and synthesis of specific inhibitors of three schistosomal peptidases. The inhibitors will be designed based on (a) the functiona...

CE - Biochemie

  • 2009 - 2012
    • •
  • 3 138 tis. Kč
    • •
  • 3 138 tis. Kč
    • •
  • GA ČR
Project

Substituted imidazopyrimidines Structure-based design and development of specific inhibitors of cancer-related protein kinases (GA19-08410S)

. Several kinase inhibitors have been approved as therapeutics for certain cancer types, but there are numerous indications, which still await selective inhibitors to be developed. This project is focused on development of small...

Medicinal chemistry

  • 2019 - 2021
    • •
  • 7 291 tis. Kč
    • •
  • 7 291 tis. Kč
    • •
  • GA ČR
Project

Advanced preiclinical progression of new highly selective inhibitors of kinase DDR1 (NW24-08-00280)

Development of protein kinase inhibitors represent a very attractive area, especially in modern oncology – to this date more than 70 small-molecule kinase inhibitors have been approved for clinical use. While some ...

Medicinal chemistry

  • 2024 - 2027
    • •
  • 13 919 tis. Kč
    • •
  • 13 919 tis. Kč
    • •
  • MZ
Project

The molecular mechanism of telomerase inhibition targeted defeat of cancer cell proliferation (GA16-20255S)

for targeting of small molecule inhibitors, using high-throughput screening in cancer cells in the applicant‘s laboratory will be fully complementary to single-molecule fluorescence......

BO - Biofyzika

  • 2016 - 2018
    • •
  • 7 569 tis. Kč
    • •
  • 6 840 tis. Kč
    • •
  • GA ČR
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