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1 253 (0,17s) •

Project

Molecular mechanism of spliceosomal snRNP formation (GA21-04132S)

Small nuclear ribonucleoprotein (snRNP) particles are key components of the spliceosome that catalyzes pre-mRNA splicing. The biogenesis of snRNP particles takes as a potential chaperone necessary for biogenesis of...

Biochemistry and molecular biology

  • 2021 - 2023
    • •
  • 9 023 tis. Kč
    • •
  • 9 023 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of snRNP quality control (GA24-11157S)

Small nuclear ribonucleoprotein particles (snRNPs) are key components of the spliceosome that catalyzes pre-mRNA splicing. The biogenesis of snRNP occurs in several and incomplete/defective particles. We will speci...

Biochemistry and molecular biology

  • 2024 - 2026
    • •
  • 12 007 tis. Kč
    • •
  • 11 830 tis. Kč
    • •
  • GA ČR
Project

Principles of snRNP sequestration into cellular structures (GA18-10035S)

Small nuclear ribonucleoprotein particles (snRNPs) are the key components of the spliceosome that catalyze pre-mRNA splicing. Assembly of snRNPs is a multistep process and mistakes in snRNP formation cause several ...

Cell biology

  • 2018 - 2020
    • •
  • 7 865 tis. Kč
    • •
  • 7 376 tis. Kč
    • •
  • GA ČR
Project

Assembly of small ribonucleoprotein particles in the cell nucleus (GA301/05/0601)

Spliceosomal small nuclear ribonucleoprotein particles (snRNPs) are distributed (CBs). A role for CBs in snRNP metabolism has been proposed but it is not well understood. Here we propose to test the hypothesis that CBs are ...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 3 973 tis. Kč
    • •
  • 3 932 tis. Kč
    • •
  • GA ČR
Project

Quality control of spliceosomal snRNP assembly (GA15-00790S)

Biogenesis of small nuclear ribonucleoprotein particles (snRNPs) is a complex formation of snRNPs. Our preliminary data showed that inhibition of different steps in snRNP biogenesis results in accumulation of stall...

EA - Morfologické obory a cytologie

  • 2015 - 2017
    • •
  • 5 230 tis. Kč
    • •
  • 5 230 tis. Kč
    • •
  • GA ČR
Project

Spliceosomal snRNP assembly and surveillance in Drosophila melanogaster (LH14033)

that control formation of snRNPs in human and fruit fly. We will mainly concentrate on newly imported snRNPs to the nucleus and the role of coilin and Cajal bodies in final stepsof snRNP assembly. The main aim is divided i...

EB - Genetika a molekulární biologie

  • 2014 - 2016
    • •
  • 1 769 tis. Kč
    • •
  • 1 769 tis. Kč
    • •
  • MŠMT
Project

Molecular mechanisms of nuclear structure formation (LTAUSA18103)

snRNPs are necessary for second step – formation of Cajal body. The project oligomerization and formation of Cajal bodies 3. To determine a role of incomplete snRNPs......

Cell biology

  • 2019 - 2022
    • •
  • 5 459 tis. Kč
    • •
  • 5 459 tis. Kč
    • •
  • MŠMT
Project

Prp8 RNA interactions in Retinitis pigmentosa - novel disease models to study cause and consequence of splicing errors in neurodegenerative diseases (GC18-01911J)

The PRPF8 protein is a highly conserved pre-mRNA splicing factor and a component of the U5 small ribonucleoprotein particle (U5 snRNP), which functions at the catalytic center of the spliceosome. Mutations in human PRPF8 cause autos...

Cell biology

  • 2018 - 2022
    • •
  • 6 487 tis. Kč
    • •
  • 6 241 tis. Kč
    • •
  • GA ČR
Project

Formation of splicing machinery in the context of the cell nucleus (GAP302/11/1910)

). Specifically, we plan to identify signals that target spliceosomal snRNPs in to the CB and determine, which steps in the snRNP assembly pathway are critical for CB formation......

EA - Morfologické obory a cytologie

  • 2011 - 2014
    • •
  • 6 045 tis. Kč
    • •
  • 6 045 tis. Kč
    • •
  • GA ČR
Project

Experimental and theoretical investigation of the Magnus force acting on the solid particle in fluid (IAA200600603)

with simultaneous rotation of solid particles in fluid; it causes the particle lateral movement normal to particle translational direction. Since accuracy of the available. for particle saltation), the particl...

BK - Mechanika tekutin

  • 2006 - 2010
    • •
  • 2 737 tis. Kč
    • •
  • 2 737 tis. Kč
    • •
  • AV ČR
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