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2 342 (0,082s) •

Project

Efficacy of current cytogenetics protocols for the diagnosis of chromosome abberations in tumor specimens. (NE6141)

Studying the relatioship between genotype of child solid tumors by means of cytogenetic and molecular cytogenetic techniques....

FG - Pediatrie

  • 2000 - 2002
    • •
  • 3 007 tis. Kč
    • •
  • 3 002 tis. Kč
    • •
  • MZ
Project

Application of polymer donors of nitric oxide for enhanced accumulation of cytostatics and immunomodulators in the solid tumor microenvironment (GA14-12742S)

The intention of the project is to achieve improved treatment of solid tumors by developing polymer anti-cancer therapeutics tailored for increased accumulation in tumor a novel approach to treatment of solid t...

CD - Makromolekulární chemie

  • 2014 - 2018
    • •
  • 7 398 tis. Kč
    • •
  • 7 398 tis. Kč
    • •
  • GA ČR
Project

Genetically downregulated expression of the immune checkpoint inhibitor LAIR-1 in tumor-specific T cells as a novel strategy for breaking the resistance of solid tumors to adoptive T cell (NU23-08-00071)

patients with solid tumors still do not benefit from this therapy. Adoptive T cell in the treatment of solid tumors. The failure is often caused by an inability of T cells downregulated expression of LAIR-1 to ove...

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2023 - 2026
    • •
  • 11 244 tis. Kč
    • •
  • 11 244 tis. Kč
    • •
  • MZ
Project

Predicting response to checkpoint inhibitors using complex molecular characteristic and immunoprofiling in solid tumors. (NV18-03-00339)

. The checkpoint inhibitors efficacy is not limited to the tumor tissue-type, but is evident in the broad range of solid tumors (malignant melanoma, lung, kidney, bladder, head and neck, esophageal, stomach cancer, MSI ...

Oncology

  • 2018 - 2022
    • •
  • 11 925 tis. Kč
    • •
  • 11 887 tis. Kč
    • •
  • MZ
Project

Whole exome, low-coverage genome and transcriptome sequencing as tools for precision oncology in paediatric patients with high-risk and relapsed solid tumors (NU20-03-00240)

Children with high-risk and relapsed solid tumors represent 15-20% of children for therapeutic planning in pediatric patients with high-risk solid tumors. for effective therapy is not only a detailed histopathologi...

Oncology

  • 2020 - 2023
    • •
  • 17 455 tis. Kč
    • •
  • 17 455 tis. Kč
    • •
  • MZ
Project

Analysis of expression, epigenetic and genetic changes of HNF1B in selected solid tumors (NV17-28404A)

with an increased or conversely decreased incidence of certain solid tumors, such as carcinomas genital tract tumors, and extend the analysis to other types of solid tumors tumors. Immuno-histoch...

EA - Morfologické obory a cytologie

  • 2017 - 2020
    • •
  • 16 302 tis. Kč
    • •
  • 16 302 tis. Kč
    • •
  • MZ
Project

Clinical cytogenetic and molecular genetic characterization of benign and malignant solid tumors in children. (IZ1148)

FD - Onkologie a hematologie

  • 1992 - 1997
    • •
  • 3 007 tis. Kč
    • •
  • 3 617 tis. Kč
    • •
  • MZ
Project

Pre-clinical validation of cGMP production of CAR T-cells for solid tumorstherapy (NV19-08-00147)

for hematological malignancies, but the results in solid tumors are not that encouranging yet solid tumor antigens under cGMP rules. We will focus mainly on target antigens GD2 is to establish production of CAR T-...

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2019 - 2023
    • •
  • 14 420 tis. Kč
    • •
  • 14 420 tis. Kč
    • •
  • MZ
Project

Mitochondrial dynamics and autophagy A missing link between dedifferentiation and development of resistance in pediatric solid tumors (GJ20-00987Y)

mitochondrial dynamics prevents the drug-induced resistance in pediatric solid tumors understood, especially in childhood tumors, which precludes development of effective stress caused by anticancer therapy may induce stem...

Cell biology

  • 2020 - 2022
    • •
  • 4 915 tis. Kč
    • •
  • 4 915 tis. Kč
    • •
  • GA ČR
Project

Receptor tyrosin kinases and downstream signaling pathways as possible therapeutic targets in pediatric refractory solid tumors (NV16-34083A)

and the downstream signaling pathways in high-risk refractory pediatric solid tumors. Individual or paired samples of tumor tissue taken from the individual patients should be included in this study. The native or fresh-fr...

FG - Pediatrie

  • 2016 - 2019
    • •
  • 14 468 tis. Kč
    • •
  • 14 468 tis. Kč
    • •
  • MZ
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