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304 (0,152s) •

Project

Tissue and soluble endoglin and their importance in endothelial dysfunction and atherogenesis in vivo and in vitro (GA15-24015S)

of endothelium, and its tissue and soluble form was detected in atherosclerosis. Endoglin is not conclusive. The aim of this project is to elucidate whether soluble endoglin is able with high levels of soluble...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2015 - 2017
    • •
  • 5 760 tis. Kč
    • •
  • 5 760 tis. Kč
    • •
  • GA ČR
Project

The relationship of soluble endoglin and hypercholesterolemia in patients with type 2 diabetes mellitus and the impact of therapeutical intervention. (NV17-31754A)

Soluble endoglin (Sol-Eng) levels are increased in blood during serious pathological conditions related to hypercholesterolemia, diabetes mellitus (DM), and inflammation. This grant project brings a prospective randomized study with...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2020
    • •
  • 8 915 tis. Kč
    • •
  • 8 915 tis. Kč
    • •
  • MZ
Project

The clinical significance of angiogenic markers in patients with renal cell carcinoma (NR8914)

To verify the soluble and membrane associated angiogenic factors reflected the growth activity of renal cell carcinoma and set up there prognostic value. To pick out some parameters (VEGF, bFGF, TGF, CD105) to determine the risk of progressi...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2006 - 2009
    • •
  • 3 619 tis. Kč
    • •
  • 3 616 tis. Kč
    • •
  • MZ
Project

Impact of direct endoglin modulation on the development of major complications of metabolic syndrome atherogenesis and non-alcoholic steatohepatitis (GA22-14961S)

Endoglin (Eng) plays a crucial role in the pathogenesis of endothelial dysfunction, atherogenesis, liver fibrosis, and non-alcoholic steatohepatitis (NASH). Carotuximab is a monoclonal antibody that directly affects the expression, and signa...

Pharmacology and pharmacy

  • 2022 - 2024
    • •
  • 8 954 tis. Kč
    • •
  • 8 954 tis. Kč
    • •
  • GA ČR
Project

Angiogenesis, plasma cell kinetics, parameters of microenvironments of bone marrow and bone metabolism in monoclonal gammopathy of undetermined significance and initial phases of multiple myeloma (NR9500)

Comparison of microvessel density and endothelial-cell proliferation inside bone marrow and serum levels of angiogenic cytokines (VEGF, HGF, bFGF, IL-17, endoglin, angiogenin and angiostatin) in MGUS, smoldering (SMM) and overt form of MM. C...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 4 306 tis. Kč
    • •
  • 4 191 tis. Kč
    • •
  • MZ
Project

Prediction of therapeutic response in ovarian cancer patients (NT14107)

effects). 2) Assay of polymorphisms of the Interleukin-8 gene, endoglin, FGF...

FK - Gynekologie a porodnictví

  • 2013 - 2015
    • •
  • 7 804 tis. Kč
    • •
  • 7 804 tis. Kč
    • •
  • MZ
Project

Soluble cytokine receptors - prognostic factor in breast cancer (NC6593)

The aim of the proposed study is to follow prospectively plasma levels of TNF, its soluble receptors and soluble IL-2 receptor in patients with newly diagnosed breast cancer and to correlate them with histologic grading. Clinical st...

FD - Onkologie a hematologie

  • 2001 - 2003
    • •
  • 2 719 tis. Kč
    • •
  • 2 686 tis. Kč
    • •
  • MZ
Project

Prediction of Solubility for Large Molecules in Solvents by Parallelized Molecular Simulation Methods (IAA4072309)

. The parallelized simulation methods will be applied to prediction of solubilities of large molecules in different solvents. Examplex are solubility of MTBE in water or solubility......

CF - Fyzikální chemie a teoretická chemie

  • 2003 - 2005
    • •
  • 1 529 tis. Kč
    • •
  • 1 309 tis. Kč
    • •
  • AV ČR
Project

Background data for pressurized hot water extraction aqueous solubilities of polycyclic heteroaromatic compounds (GA203/07/0886)

new experimental data on solubility in PHW of solid polycyclic aromatic will be carried out using dynamic saturation method. 2) To convert the measured solubilities) To develop a predictive correlation of solubility of sol...

CB - Analytická chemie, separace

  • 2007 - 2009
    • •
  • 1 513 tis. Kč
    • •
  • 1 513 tis. Kč
    • •
  • GA ČR
Project

The Synthesis of Water-soluble Derivative of Neuroactive Steroids and Evaluation of Their Neuropsychotropic Activity (NL4668)

Water-soluble derivatives of neuroactive steroids will be synthesized and their anxiolytic,sedative and other neuropsychotropic activities will be tested in animalis. The structure of the steroids will be modified in order to increase their ...

FR - Farmakologie a lékárnická chemie

  • 1998 - 2000
    • •
  • 2 317 tis. Kč
    • •
  • 1 460 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 304