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1 585 (0,172s) •

Project

Spatially resolved single-cell transcriptomic map of human ischemic brain (GA25-16979S)

brain using single-nucleus and spatial transcriptomics. We will measure the response modeling, we aim to produce a spatially resolved transcriptomic map of the human......

Neurosciences (including psychophysiology)

  • 2025 - 2027
    • •
  • 8 991 tis. Kč
    • •
  • 8 991 tis. Kč
    • •
  • GA ČR
Project

Spatiotemporal transcriptome and proteome analysis of α-Synuclein pathology in Parkinson’s disease Identification of cell type-specific vulnerability and tolerance mechanisms (9F24003)

1. Spatiotemporal analysis of neuronal, glial and immune cell responses at transcriptome and proteome level in vulnerable and more resistant brain regions; 2. Multi-omic bioinformatics analysis of spatiotemporal gene and protein expression c...

Other medical science

  • 2024 - 2027
    • •
  • 6 633 tis. Kč
    • •
  • 6 633 tis. Kč
    • •
  • MŠMT
Project

Astrocyte-microglia communication as a target for stroke therapy (GA23-05327S)

in mouse model using the state-of-art methods for single-cell and spatial transcriptomic analysis. The integration of both modalities will identify opportunities by astrocytes and microglia in ischemic mouse brain with spatial<...

Neurosciences (including psychophysiology)

  • 2023 - 2025
    • •
  • 10 874 tis. Kč
    • •
  • 10 874 tis. Kč
    • •
  • GA ČR
Project

Redox reprogramming of the proteome in therapeutic resistance of Myelodysplastic syndrome (GA24-10353S)

programs that lead to the emergence of RLCs. Redox and spatial proteomic and transcriptomic screening of primary patient samples will provide deep insight......

Cell biology

  • 2024 - 2026
    • •
  • 10 988 tis. Kč
    • •
  • 10 973 tis. Kč
    • •
  • GA ČR
Project

Interaction of the pertussis agent with ciliated epithelia of nasal mucosa (GX25-18104X)

and spatial transcriptomics we shall unravel how adhering bacteria manipulate the infected...

Microbiology

  • 2025 - 2029
    • •
  • 50 000 tis. Kč
    • •
  • 50 000 tis. Kč
    • •
  • GA ČR
Project

A humanized organoid-based platform for stroke modelling and mRNA-based therapeutic intervention (GA24-11364S)

as a new platform for stroke modelling and drug testing. Using single-cell and spatial transcriptomics, we will characterize cellular pathophysiological mechanisms of ischemic......

Neurosciences (including psychophysiology)

  • 2024 - 2026
    • •
  • 10 693 tis. Kč
    • •
  • 10 693 tis. Kč
    • •
  • GA ČR
Project

Spatial proteomics of Euglena gracilis with a focus on its pellicle structure and chloroplast protein import (GA23-07277S)

Research on Euglena gracilis has reached several milestones: the sequencing of its transcriptome and partial genome, followed by proteomic studies on its of Euglena by using LOPIT spatial proteomics, which has been very helpful in d...

Cell biology

  • 2023 - 2025
    • •
  • 10 422 tis. Kč
    • •
  • 10 422 tis. Kč
    • •
  • GA ČR
Project

Comparative transcriptomic analysis of regeneration in head and neck cancer as a new strategy to search cancer prognostic markers (NW24-03-00459)

potential back in established model. We will combine results from spatial transcriptomics, histology, and functional validation to identify set of the most reliable......

Oncology

  • 2024 - 2027
    • •
  • 15 032 tis. Kč
    • •
  • 15 032 tis. Kč
    • •
  • MZ
Project

Genomic and Transcriptomic Analyis of Insect Diapause (LUAUS25273)

A) Obtaining a high-quality reference genome of the firebug Pyrrhocoris apterus B) Obtaining a high-quality reference transcriptome of the firebug Pyrrhocoris apterus C) Annotating both the genome and transcriptome D) Conducting dif...

Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

  • 2025 - 2028
    • •
  • 9 332 tis. Kč
    • •
  • 9 332 tis. Kč
    • •
  • MŠMT
Project

Tower of Babel Mitochondrial-nuclear interactions in the gynodioecious species Silene vulgaris investigated with transcriptomics. (GA16-09220S)

interesting owing to its importance in agriculture. We will apply the transcriptomic and nucleus-derived transcriptomes. We will clarify the pathways followed by specific CMS......

EF - Botanika

  • 2016 - 2020
    • •
  • 4 964 tis. Kč
    • •
  • 4 857 tis. Kč
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  • GA ČR
  • 1 - 10 out of 1 585