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7 312 (0,121s) •

Project

Receptor-specific radiopharmaceuticals for imaging and therapy of cancers (GA305/07/0535)

Receptor imaging with radiolabelled receptor-specific peptides has proven and biodistribution of new radiolabelled receptor-specific peptides for diagnosis or treatment of somatostatin (or cholecystokinin ...

FR - Farmakologie a lékárnická chemie

  • 2007 - 2009
    • •
  • 2 670 tis. Kč
    • •
  • 2 670 tis. Kč
    • •
  • GA ČR
Project

Vital role of plasma membrane in cell interaction with exogenous proteins interaction of yeast plasma membrane with zymocines (GA204/00/0629)

with the toxin(s), in particular: (1) specificity of S. cerevisiae plasma membrane receptors, physiology or differentiation. Plasma membrane receptors are vital for this process toxin receptors of yeasts. The obje...

EE - Mikrobiologie, virologie

  • 2000 - 2002
    • •
  • 3 101 tis. Kč
    • •
  • 1 996 tis. Kč
    • •
  • GA ČR
Project

Influence of allosteric modulators on specificity of coupling with G-proteins and desensitization of muscarinic receptors (GA305/05/0452)

In spite of preferential coupling of muscarinic receptors to distinct classes modulators that bind at secondary domains on the receptor not only influence receptor affinity for orthosteric ligands but also partially activat...

ED - Fyziologie

  • 2005 - 2007
    • •
  • 4 992 tis. Kč
    • •
  • 4 992 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of syncytin-mediated cell-to-cell fusion in placenta (IAA500520709)

is to identify the specific receptor for HERV-FRD family syncytin-2 and characterise it further as to the tissue-specific expression and the binding site for the viral glycoproteins of human endogenous retroviruses, which ...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 2 478 tis. Kč
    • •
  • 2 478 tis. Kč
    • •
  • AV ČR
Project

Novel and specific anion receptors for use in sensor technology (OC 134)

design of new substances aimed at complexation of anionsin polar environment, characterisation of interaction process anion-ligand...

JJ - Ostatní materiály

  • 2006 - 2009
    • •
  • 1 300 tis. Kč
    • •
  • 1 300 tis. Kč
    • •
  • MŠMT
Project

Influence of cholesterol on muscarinic receptor signalling (GP305/05/P209)

It has been generally accepted that muscarinic receptors play an important role receptors. For this purpose we shall exploit Chinese hamster ovary cells expressing individual subtypes of muscarinic receptors. Effects on bin...

ED - Fyziologie

  • 2005 - 2007
    • •
  • 1 146 tis. Kč
    • •
  • 1 146 tis. Kč
    • •
  • GA ČR
Project

Interactions of syncytins with specific cell receptors (GA17-14356S)

by interactions of syncytins and specific receptors on the cell surface. Syncytins 1 and 2 receptors (hASCT2/1, MFSD2) could be approached virologically by analyzing virus-cell with wild-type or mutant receptors. ...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 7 524 tis. Kč
    • •
  • 6 717 tis. Kč
    • •
  • GA ČR
Project

Study of pharmacokinetics and biodistribution of radiolabelled biologically active peptides in laboratory animals (OC B12.001)

The aim of this project is to receive new knowledge about preparation and biological behaviour of the radiolabelled receptor-specific peptides with the intention to find new radiodiagnostics or radiotherapeutics of tumours under end...

FR - Farmakologie a lékárnická chemie

  • 2001 - 2004
    • •
  • 5 106 tis. Kč
    • •
  • 1 752 tis. Kč
    • •
  • MŠMT
Project

Regulation of the gene for muscarinic acetylcholine receptors of the M2 subtype (IAA5011306)

The aim of the project is to identify the genomic regulatory elements responsible for directing cell specific expression of the mammalian M2 muscarinic receptors gene (M2RG). We will focus upon control of M2RG transcription in neura...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 3 484 tis. Kč
    • •
  • 2 413 tis. Kč
    • •
  • AV ČR
Project

Interleukins of the IL-10 family specificity and targeted modulation of interactions with receptors (GA16-20507S)

of their interaction with receptors, and ways how they preserve specificity in systems with shared receptors. Inhibitors disrupting IL–receptor interaction will be chosen by ribosomeWe plan to elucidate specif...

EB - Genetika a molekulární biologie

  • 2016 - 2018
    • •
  • 7 404 tis. Kč
    • •
  • 7 290 tis. Kč
    • •
  • GA ČR
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