All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”
EN
ČeštinaEnglish

Filters

13 (0,06s) •

Project

Changes of glycosignalig in canalicular membrane of hepatocytes in the pathogenesis of cholestasis and cholelithiasis (NB6758)

Concentration of (glyco)sphingolipids and signal proteins in the basic principle by which these domains perform their function. The sphingolipid and protein compositions of domains under physiological conditions and in cholestasis w...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 2 845 tis. Kč
    • •
  • 2 810 tis. Kč
    • •
  • MZ
Project

Toxicolipidomics emerging pathways of toxicity of organic pollutants (GA17-27669S)

on sphingolipids and eicosanoids) will be correlated with gene/protein expression, markers...

DN - Vliv životního prostředí na zdraví

  • 2017 - 2021
    • •
  • 5 798 tis. Kč
    • •
  • 5 798 tis. Kč
    • •
  • GA ČR
Project

A new regulatory pathway in leukotriene biosynthesis in mast cells (GA18-18521S)

of ORMDL3 in sphingolipids production. Although leukotrienes are crucial in asthma regulates biosynthesis not only sphingolipids but also leukotrienes. We will prepare......

Immunology

  • 2018 - 2022
    • •
  • 8 877 tis. Kč
    • •
  • 7 629 tis. Kč
    • •
  • GA ČR
Project

ORMDL sphingolipid biosynthesis regulator 2 in immunoreceptor activation (GA17-20915S)

ORMDL1,2, and 3 proteins are key regulators of serine palmitoyltransferase, which catalyzes the initial steps in sphingolipid synthesis. In our previous study we found that ORMDL3 is a negative regulator of activation by the high-affinity Ig...

EC - Imunologie

  • 2017 - 2021
    • •
  • 8 217 tis. Kč
    • •
  • 7 671 tis. Kč
    • •
  • GA ČR
Project

Prospective study on early pancreatic cancer detection and therapy monitoring using lipidomic profiling by mass spectrometry (NU21-03-00499)

to quantify at least 200 lipids from 5 lipid categories (phospholipids, sphingolipids, SM 39:1, SM 42:1, etc.) and upregulated phospholipids and sphingolipids......

Analytical chemistry

  • 2021 - 2025
    • •
  • 14 053 tis. Kč
    • •
  • 13 978 tis. Kč
    • •
  • MZ
Project

Regulation of cathepsins in breast cancer therapy (IAA400550705)

. Third, sphingolipids and glycosaminoglycans will be screened for modulation of pCD...

CE - Biochemie

  • 2007 - 2010
    • •
  • 3 115 tis. Kč
    • •
  • 3 115 tis. Kč
    • •
  • AV ČR
Project

Use of tandem mass spectrometry of glycosphinoglipids for diagnosis of lysosomal storage diseases and for monitoring of treatment in Fabry disease. (NR8167)

Inherited lysosomal storage disorders are characterized by accumulation of different substrates due to the deficiency of specific lysosomal hydrolases, defects of protein activators or transport mechanism. In Fabry disease, deficiency of ?-galactosid...

FG - Pediatrie

  • 2004 - 2006
    • •
  • 2 008 tis. Kč
    • •
  • 1 821 tis. Kč
    • •
  • MZ
Project

Function of specific membrane microdomains in lipid homeostasis (GA19-04052S)

Cellular lipidome is a subject of continuous, multilayer adaptation reacting to external stimuli as well as to actual cell metabolism. In the project we focus to those homeostatic processes, which take place on specialized microdomains of biological ...

Cell biology

  • 2019 - 2022
    • •
  • 5 993 tis. Kč
    • •
  • 5 993 tis. Kč
    • •
  • GA ČR
Project

Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level (GA13-23891S)

The general objective of this interdisciplinary project is to develop and study membrane models of the lipid skin barrier in atopic dermatitis and other skin diseases to gain a detailed insight into the role of lipid abnormalities in these diseases o...

FR - Farmakologie a lékárnická chemie

  • 2013 - 2017
    • •
  • 9 734 tis. Kč
    • •
  • 9 734 tis. Kč
    • •
  • GA ČR
Project

Biophysical properties of Lipid Droplets and their implications in Gaucher disease and Parkinsons disease (EH22_010/0008585)

in biophysical properties of LD in cell models of GD. Data show that the sphingolipid GlcCer...

Biophysics

  • 2024 - 2026
    • •
  • 3 904 tis. Kč
    • •
  • 987 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 13