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32 (0,064s) •

Project

Analysis of free DNA and miRNA as markers of muscle damage in statin-treated patients (NU21-01-00146)

Statins reduce significantly increased plasma cholesterol values and also the risk of cardiovascular events. Although statin treatment seems to have rather low risk of side effects, given the number of patients on statins t...

Endocrinology and metabolism (including diabetes, hormones)

  • 2021 - 2025
    • •
  • 9 627 tis. Kč
    • •
  • 9 518 tis. Kč
    • •
  • MZ
Project

Analysis of the genetic predisposition to the statin-induced side effects (NT11307)

side effects of statins treatment that has to be started with the majority of patients with dyslipidaemia. Despite the good tolerance of statins undesirable effects (e.g., myopathy, myalgia) occur with 3-10% of the treated. With ~1...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2010 - 2014
    • •
  • 4 758 tis. Kč
    • •
  • 4 758 tis. Kč
    • •
  • MZ
Project

Studies of anticancer effects of statins (NT13112)

Statins (inhibitors of HMG-CoA reductase) belong to widely used drugs in human action, statins exert a number of other pleitropic biological effetcs, which are increasingly discussed. Potential anticancer effects of statins...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2015
    • •
  • 6 265 tis. Kč
    • •
  • 6 265 tis. Kč
    • •
  • MZ
Project

Influence of statins on repolarisation phase of cardiomyocytes (NS10454)

Statins are nowadays one of the most used drugs. Beside the influence on lowering the levels of cholesterol and triglycerides, the "non-lipid" effects were described. Influence on repolarisation phase of cardiomyocytes was not studied in det...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2009 - 2011
    • •
  • 1 568 tis. Kč
    • •
  • 1 568 tis. Kč
    • •
  • MZ
Project

Role of rare variants in genetic predisposition to statin myopathy (NT14025)

The project objective is to determine the contribution of rare gene variants in SLCO1B1, SLCO1B3, and other known or unknown candidate genes to the mechanism of statin-induced myopathy. The presence of variants in approximately 70 patients w...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2015
    • •
  • 5 865 tis. Kč
    • •
  • 5 865 tis. Kč
    • •
  • MZ
Project

The development and application of new biotechnological methods to study relationship of phenotypes, genotypes and response to statin therapy upon lipoprotein metabolism (1A8689)

Statins are administered to a wide range of individuals on an empirical basis. Investigation of the phenotype and genotype influences on treatment response will allow biotechnological methods to study relationship of phenotypes, genotypes an...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2008
    • •
  • 4 963 tis. Kč
    • •
  • 4 541 tis. Kč
    • •
  • MZ
Project

Effects of environmental factors, gene predisposition and psychological impact of genetic testing on efficacy of lipid lowering treatment (NS10579)

Evaluation of the impact of genetic determination of dyslipidemia on therapeutic efficacy of statin treatment by assessment of gene polymorphisms. Assessment of impact of genetic testing awareness on efficacy of statin treatment.......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2009 - 2011
    • •
  • 4 883 tis. Kč
    • •
  • 4 883 tis. Kč
    • •
  • MZ
Project

The influence of fibrates on homocystein metabolism and its impact on endothelial dysfunction and coagulation status in dyslipidemic patients. (NL6817)

To establish the impact of fibrate treatment in comparison with statins on plasma homocystein levels. To establish the impact of interaction of fibrate status in comparison with statins. To study the potential to influence polymorph...

FR - Farmakologie a lékárnická chemie

  • 2001 - 2003
    • •
  • 3 086 tis. Kč
    • •
  • 3 045 tis. Kč
    • •
  • MZ
Project

Spray nebulization drying - new way to preservation of nutraceutics activities. (TH02010345)

- Optimization of CASND drying technology - Device optimizing - prototype proposition - Examination of CASND drying effectivity and encapsulation of biologically active materials: statins isolated from Monascus purpureus microorganism , p...

JP - Průmyslové procesy a zpracování

  • 2017 - 2020
    • •
  • 7 368 tis. Kč
    • •
  • 4 420 tis. Kč
    • •
  • TA ČR
Project

Can Statins Attenuate a development of cholestatic liver disease? (NS9739)

effect of statins including the effect on mitochondria function and the dose...

FJ - Chirurgie včetně transplantologie

  • 2008 - 2010
    • •
  • 2 273 tis. Kč
    • •
  • 2 273 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 32