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Project

Pleiotropic effects of hypolipidemics (GA305/09/1177)

This project is an attempt to study how (i)  an application of a hypolipidemic drug (statin) or (ii) administration of silybin and silymarin (with hypolipidemic effects) and (iii) the hereditary status of the organism (rat hereditary hypertriglycerid...

FR - Farmakologie a lékárnická chemie

  • 2009 - 2011
  • 1 763 tis. Kč
  • 1 763 tis. Kč
  • GA ČR
Project

The relationship of soluble endoglin and hypercholesterolemia in patients with type 2 diabetes mellitus and the impact of therapeutical intervention. (NV17-31754A)

Soluble endoglin (Sol-Eng) levels are increased in blood during serious pathological conditions related to hypercholesterolemia, diabetes mellitus (DM), and inflammation. This grant project brings a prospective randomized study with 104 patients (90 ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2020
  • 8 915 tis. Kč
  • 8 915 tis. Kč
  • MZ
Project

Blood flow modelling in intracranial vessels in relationship to endothelium changes and development of intracranial aneurysms (NU22-08-00124)

Rupture of intracranial aneurysms (IA) leads to one of the most severe types of stroke with high morbidity and mortality. Deviations in hemodynamics inside an IA are associated with inflammation reaction in the vessels including activation of macroph...

Clinical neurology

  • 2022 - 2025
  • 16 132 tis. Kč
  • 16 132 tis. Kč
  • MZ
Project

Analysis of free DNA and miRNA as markers of muscle damage in statin-treated patients (NU21-01-00146)

Statins reduce significantly increased plasma cholesterol values and also the risk of cardiovascular events. Although statin treatment seems to have rather low risk of side effects, given the number of patients on statins the prevalence of side effec...

Endocrinology and metabolism (including diabetes, hormones)

  • 2021 - 2025
  • 9 627 tis. Kč
  • 9 518 tis. Kč
  • MZ
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