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14 (0,066s) •

Project

Impact of direct endoglin modulation on the development of major complications of metabolic syndrome atherogenesis and non-alcoholic steatohepatitis (GA22-14961S)

Endoglin (Eng) plays a crucial role in the pathogenesis of endothelial dysfunction, atherogenesis, liver fibrosis, and non-alcoholic steatohepatitis (NASH). Carotuximab is a monoclonal antibody that directly affects the expression, and signa...

Pharmacology and pharmacy

  • 2022 - 2024
    • •
  • 8 954 tis. Kč
    • •
  • 8 954 tis. Kč
    • •
  • GA ČR
Project

Complex lifestyle modification in the treatment of non-alcoholic fatty liver disease (NU23-01-00288)

-alcoholic steatohepatitis) during lifestyle modification is available. The project...

Endocrinology and metabolism (including diabetes, hormones)

  • 2023 - 2026
    • •
  • 14 798 tis. Kč
    • •
  • 14 798 tis. Kč
    • •
  • MZ
Project

The effect of ectopic fat accumulation and chronic inflammation on the development of liver injury and disorders associated with insulin resistance. (NS10504)

The project is focussed on risk factors responsible for the NAFLD pathological progression towards non-alcoholic steatohepatitis and for the development of hepatic IR. Issues to be solved: 1. the alterations in liver Tg metabolism associated...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2009 - 2011
    • •
  • 6 213 tis. Kč
    • •
  • 6 137 tis. Kč
    • •
  • MZ
Project

In vitro 3-dimensional liver models to study cyanotoxin-induced chronic hepatotoxicity and liver diseases. (GA19-19143S)

Human exposure to hepatotoxic cyanotoxins microcystin-LR and cylindrospermopsin can induce not only an acute but also chronic liver damage, which can result into the development of liver cancer as well as other diseases, such as nonalcoholic fatty li...

Public and environmental health

  • 2019 - 2023
    • •
  • 5 800 tis. Kč
    • •
  • 5 722 tis. Kč
    • •
  • GA ČR
Project

Novel inhibitors of lipolysis in the treatment of lipid a glucose metabolism in obstructive sleep apnea syndrome (NU21-01-00259)

-alcoholic steatohepatitis. Unfortunately, adherence to state-of-the-art therapy (specifically: Type 2 diabetes mellitus, dyslipidemia and non-alcoholic steatohepatitis......

Endocrinology and metabolism (including diabetes, hormones)

  • 2021 - 2024
    • •
  • 12 841 tis. Kč
    • •
  • 12 841 tis. Kč
    • •
  • MZ
Project

Simplified method for quantification of specific genes expression (FV20479)

of steatohepatitis and fibrosis. Outcome of the project will be prototypes of generally feasible...

EB - Genetika a molekulární biologie

  • 2017 - 2020
    • •
  • 9 995 tis. Kč
    • •
  • 7 971 tis. Kč
    • •
  • MPO
Project

The role of C reactive protein in the pathogenesis of metabolic syndrome nutritional and pharmacological interventions (NS9757)

We will analyze the role of C reactive protein (CRP) in the pathogenesis of insulin resistance, dyslipidemia and hypertension in a new line of spontaneously hypertensive rat (SHR) with a transgenic expression of human CRP gene in adipose tissue. Thes...

EB - Genetika a molekulární biologie

  • 2008 - 2011
    • •
  • 5 777 tis. Kč
    • •
  • 5 694 tis. Kč
    • •
  • MZ
Project

The role of protective mechanisms, oxidative stress and inflammatory reaction in the progreof liver damage in patient with metabolic syndrome and possible influence of antioxidative factors on the prevention of liver damage in experimental model of NASH. (NT11247)

The development of liver disease in metabolic syndrome (MS) could be mediated by e.g. oxidative stress or inflammatory reaction. An ability of organism to react to such stimuli could influence the course and severity of non-alcoholic steatohepati...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2010 - 2014
    • •
  • 3 663 tis. Kč
    • •
  • 3 662 tis. Kč
    • •
  • MZ
Project

The triggers of Proteobacteria dysbiosis and its role in the pathogenesis of immune-mediated and metabolic diseases (GA20-09732S)

The worldwide incidence of many immune-mediated and metabolic diseases, initially affecting only the wealthy Western countries, is increasing rapidly. For example, the prevalence of the non-alcoholic fatty liver disease which may progress through non...

Microbiology

  • 2020 - 2022
    • •
  • 7 633 tis. Kč
    • •
  • 7 633 tis. Kč
    • •
  • GA ČR
Project

Monitoring of hepatic fat metabolism using Magnetic Resonance methods (NV16-28427A)

Non-alcoholic fatty acid liver disease (NAFLD, steatosis) is the most frequent chronic liver disease in western countries (prevalence ~30%). The disease often progresses to steatohepatitis (NASH) and further even to cirrhosis and hepatocellu...

FP - Ostatní lékařské obory

  • 2016 - 2020
    • •
  • 7 034 tis. Kč
    • •
  • 6 999 tis. Kč
    • •
  • MZ
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