Filters
Relationships of steroid metabolism to the patogenesis and treatment of epilepsy (1A8649)
endocrinopathies influencing at least the course of epilepsy. Some circulating steroids surpass produced steroids, modulate also the ionotropic membrane receptors of neuronal cells influencing the neuronal activity. We will concent...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2005 - 2009 •
- 8 286 tis. Kč •
- 8 188 tis. Kč •
- MZ
Řešení projektu: 1. 8. 2005 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Ministerstvo zdravotnictví
Influence of smoking and its cessation on endocrine system (NR9055)
In common steroids, the effect of smoking was investigated but in neuroactive steroids there are a nuber of metabolic pathawas that were not examined. Nicotine the effect that was formerly found in C19 steroids in C21 s...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2006 - 2009 •
- 6 948 tis. Kč •
- 6 380 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2006 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (92%)
Poskytovatel: Ministerstvo zdravotnictví
The role of steroid sulfates in steroid metabolism and their diagnostic meaning. (NB5398)
Investigation of influencing the kinetics of formation and matabolism of steroid sulfates by free radical scavengers and diagnostic utilization of possible relation between autoimunne diseases and plasma levels of steroid sulfates.....
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 1999 - 2001 •
- 2 377 tis. Kč •
- 1 888 tis. Kč •
- MZ
Řešení projektu: 1. 1. 1999 - 1. 1. 2001
Uznané náklady
Podpora ze státního rozpočtu (79%)
Poskytovatel: Ministerstvo zdravotnictví
The smoking cessation and hormonal homeostasis oriented to neuroactive steroids (NS10215)
The influence of smoking on the biosynthesis of steroids is still not fully enzyme of the synthesis of neuroactive steroids. We shall focus on the influence of smoking on the synthesis of neuroprotective and immunomodulating 7-hydro...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2009 - 2011 •
- 4 441 tis. Kč •
- 4 441 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2009 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
To the role of neuroactive steroids Their metabolism and its influencing under physiological and pathological conditions (NB6702)
The proposed grant is studying the interactions between the levels of neuroactive steroids and homocysteine in physiological and pathological conditions and the influence of exogenous and endogenous factors on the activity of steroidogenic, ...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2001 - 2003 •
- 2 262 tis. Kč •
- 1 956 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2001 - 1. 1. 2003
Uznané náklady
Podpora ze státního rozpočtu (86%)
Poskytovatel: Ministerstvo zdravotnictví
The role of steroids as modulators of internal milieu in human semen fluid; a contribution to the endocrinology of male reproduction. (NB6890)
Immunomodulatory and immunosuppressive steroids, together with relevant cytokines, will be determined in ejaculate and blood of healthy men and in men with sexual disorders and impairment of fertility. The answer to the question is expected ...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2002 - 2004 •
- 3 466 tis. Kč •
- 3 466 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2002 - 1. 1. 2004
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Prediction of gestational diabetes on the basis of steroid metabolism (NV17-30528A)
of numerous isoforms of steroid sensitive ion channels in pancreas demonstrate their role in the regulation of insulin secretion and insulin sensitivity. An extensive rise of steroid levels in pregnancy prompted us to address a que...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2017 - 2021 •
- 11 201 tis. Kč •
- 11 154 tis. Kč •
- MZ
Řešení projektu: 1. 4. 2017 - 31. 12. 2021
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
New Methods for Determination of Neuroactive Steroids and Their Polar Conjugates in Human Tissues and Serum (NR7768)
We intend to develop new high sensitive and selective methods for determination of neuroactive pregnanolone isomers by means of gass chromatgraphy with mass spectrometry (GC-MS) with new derivatization techniques. The new quick and sensitive method o...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2004 - 2006 •
- 4 691 tis. Kč •
- 4 194 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (89%)
Poskytovatel: Ministerstvo zdravotnictví
The Synthesis of Water-soluble Derivative of Neuroactive Steroids and Evaluation of Their Neuropsychotropic Activity (NL4668)
Water-soluble derivatives of neuroactive steroids will be synthesized and their anxiolytic,sedative and other neuropsychotropic activities will be tested in animalis. The structure of the steroids will be modified in order to increa...
FR - Farmakologie a lékárnická chemie
- 1998 - 2000 •
- 2 317 tis. Kč •
- 1 460 tis. Kč •
- MZ
Řešení projektu: 1. 1. 1998 - 1. 1. 2000
Uznané náklady
Podpora ze státního rozpočtu (63%)
Poskytovatel: Ministerstvo zdravotnictví
Steroids and thyreopathies (NB6313)
Steroids with newly revealed immunoprotective and antiglucocorticoid activity will be investigated in groups of most frequent thyreopathies as Hashimoto ´s thyroiditis, Graves-Basedow diseases and in subclinical hypo- or hyperthyreosis. Besi...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2000 - 2002 •
- 2 037 tis. Kč •
- 1 662 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2000 - 1. 1. 2002
Uznané náklady
Podpora ze státního rozpočtu (82%)
Poskytovatel: Ministerstvo zdravotnictví
- 1 - 10 out of 180