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14 (0,072s) •

Project

Cholinergic control of striatal-based behavior determining the role of nicotinic acetylcholine receptors expressed by striatal GABAergic interneurons (GJ19-07983Y)

expressed by GABAINs in the dorsal striatum. The resulting mouse models will be tested in the neurobiology of striatum-related neuropsychiatric disorders.......

Neurosciences (including psychophysiology)

  • 2019 - 2022
    • •
  • 5 174 tis. Kč
    • •
  • 5 174 tis. Kč
    • •
  • GA ČR
Project

Mechanism and possibilities of pharmacological intervention in presynaptic regulation of acetycholine release (GA305/98/0469)

the brain cortex , hippocampus and striatum, and on primary neuronal cultures from the striatum and basal forebrain. The aim will be to determine which subtypes of calcium......

ED - Fyziologie

  • 1998 - 2000
    • •
  • 2 887 tis. Kč
    • •
  • 2 470 tis. Kč
    • •
  • GA ČR
Project

What is the role of mesolimbic reward circuit in the long-term effect of prenatal methamphetamine exposure in rats? (GAP303/10/0580)

) and striatum andthere from ventral striatum (NAc) and dorsal striatum (caudate/putamen...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2014
    • •
  • 18 203 tis. Kč
    • •
  • 18 203 tis. Kč
    • •
  • GA ČR
Project

Phage-based targeted neural stimulation in neurodegenerative diseases (8F21004)

Engineering and functionalization of NPhs constructs, Assessment of in vitro biocompatibility, BBB crossing and targeting efficacy of NPhs constructs, Selective in vitro neuronal activation by NPhs,......

Other medical science

  • 2021 - 2024
    • •
  • 6 571 tis. Kč
    • •
  • 6 571 tis. Kč
    • •
  • MŠMT
Project

The experimental model of Huntington's disease The reaction of the subependymal layer of lateral ventricles to neurodegenerative process within the striatum, and to the fetal neural graft. (NF7594)

the striatum (neurotoxic lesion) and by the following grafting of the fetal neural tissue....

EA - Morfologické obory a cytologie

  • 2003 - 2005
    • •
  • 2 557 tis. Kč
    • •
  • 2 476 tis. Kč
    • •
  • MZ
Project

The role of serotonin activity in unique action of atypical antipsychotics in animal model of schizophrenia (NL7684)

and the striatum. The results will be compared with the effect of atypical APDs. The effect of serotoninmodulation on dopamine levels in the prefrontal cortex and striatum will be evaluated......

FR - Farmakologie a lékárnická chemie

  • 2003 - 2005
    • •
  • 4 256 tis. Kč
    • •
  • 4 102 tis. Kč
    • •
  • MZ
Project

Detection of neuroanatomical risk factors for bipolar disorder (NR8786)

We will perform MRI volumetry of the brain in offspring of parents with bipolar disorder, both unaffected and affected by mood disorders and matched healthy controls, in order to detect primary neuroanatomical risk factors for bipolar disorder.......

FL - Psychiatrie, sexuologie

  • 2006 - 2008
    • •
  • 3 921 tis. Kč
    • •
  • 3 772 tis. Kč
    • •
  • MZ
Project

Effects of processed meat on brain regions related to reward and craving in patients with type 2 diabetes, obese subjects and healthy controls (NV15-27338A)

The mesolimbic dopaminergic system of the brain, which converges on the nucleus accumbens (part of the striatum), plays a central role in reward and craving, and this system appears to mediate hedonic food responses. Clinical studies that us...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2015 - 2018
    • •
  • 8 699 tis. Kč
    • •
  • 8 699 tis. Kč
    • •
  • MZ
Project

Neural transplantation into experimental model of Huntington's disease. (NF5400)

For patients with HD neural transplantation is the only treatment with evidently positive effects, although limited for several years. However, it is still necessary to solve a number of uncleared matters concern. relations between graft and host tis...

EA - Morfologické obory a cytologie

  • 1999 - 2001
    • •
  • 1 436 tis. Kč
    • •
  • 819 tis. Kč
    • •
  • MZ
Project

Modulation of striatal-based behavior by beta2-containing nicotinic acetylcholine receptors. A functional and morphological approach. (8J21FR022)

Aim 1: Characterizing the expression and (sub)cellular localization of beta2-containing nicotinic receptors in individual groups of striatal GABAINs. To this aim, we will use FISH, electron and super resolution microscopy. Aim 2: Identifying the fun...

Neurosciences (including psychophysiology)

  • 2021 - 2022
    • •
  • 148 tis. Kč
    • •
  • 148 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 14