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7 285 (0,233s) •

Project

Molecular basis of functional selectivity of Nsubstituted tetrahydropyridinium salts at muscarinic receptors (GA17-16182S)

disorders. Understanding of the molecular mechanisms of functional selectivity of N‑substituted tetrahydropyridinium salts and identification of their ectopic binding site and binding mechanisms may facilitate development ...

ED - Fyziologie

  • 2017 - 2019
    • •
  • 4 667 tis. Kč
    • •
  • 4 397 tis. Kč
    • •
  • GA ČR
Project

Molecular biology and structure funcition studies of multiple substitution mutants of mitochondrial uncoupling protein (GA301/98/0568)

mechanism which has been functionally verified by the applicant (Garlid, Ježek et al. J studies of the reconstituted multi-substituted UcP mutants expressed in yeast, since the single substitutions (e. g. Cys) did not brin...

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 3 255 tis. Kč
    • •
  • 2 042 tis. Kč
    • •
  • GA ČR
Project

Electronic structure of substituted magnetites (GA202/00/1601)

is believed to correspond to the localization of Fe2+ ions and its driving mechanism sensitive to the cation substitutions - the substitutions which most effectivelhinder is an ideal tool to study what happens in the s...

BM - Fyzika pevných látek a magnetismus

  • 2000 - 2002
    • •
  • 2 467 tis. Kč
    • •
  • 1 817 tis. Kč
    • •
  • GA ČR
Project

Reactivity of asymmetrically substituted epimino pyranoses (IAA400720703)

. A ionic SN1-like mechanism in competition with SN2 mechanism is expected to control-2,3-epimines is more likely to follow SN2 mechanism in a kinetically followthese postulated mechanisms, we will be able to prepa...

CC - Organická chemie

  • 2007 - 2009
    • •
  • 603 tis. Kč
    • •
  • 603 tis. Kč
    • •
  • AV ČR
Project

ConSlag - research and verification of construction applications with increased added value in case of steel slag (TJ01000435)

of using of specific type of steel slags in asphalt mixtures as a substitute for aggregate with higher mechanical resistance - Possibilities of using finely crushed or mechanical-chemically activated (pulverized) steel sla...

Civil engineering

  • 2018 - 2019
    • •
  • 1 826 tis. Kč
    • •
  • 1 486 tis. Kč
    • •
  • TA ČR
Project

THE OPTIMALIZATION OF PHYSICAL CHARACTERISTICS OF VASCULAR SUBSTITUTES FOR LOW FLOW (NT13302)

characteristics, the present differences between long-term success of biological substitutes substitutes under the same conditions On the base of almost half century experience with the research of vascular substitutes we ...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2012 - 2015
    • •
  • 8 052 tis. Kč
    • •
  • 8 052 tis. Kč
    • •
  • MZ
Project

Intramolecular Nucleophilic Substitution. Kinetics and Mechanism of the Tandem Recyclization Reaction (GP203/02/D170)

The aim of the submitted project is a study of kinetics and mechanism of tandem recyclation reaction of substituted S-(1-phenylpyrrolidin-2-on-3-yl)isothiuronium salts to the corresponding 2-imino-5-[2-(phenylamino)ethyl]thiazolidin...

CC - Organická chemie

  • 2002 - 2004
    • •
  • 1 100 tis. Kč
    • •
  • 250 tis. Kč
    • •
  • GA ČR
Project

Uncovering the mechanism underlying the tumor-suppressive effects of miR-215 and its substitution as new therapeutic strategy in colorectal cancer (GA16-18257S)

to our preliminary data, substitution of miR-215 lead to cell cycle arrest in G1. The main aim of this project is to uncover the molecular mechanisms underlying. Further, substitution of miR-215 as new therapeutic strategy...

FR - Farmakologie a lékárnická chemie

  • 2016 - 2020
    • •
  • 7 158 tis. Kč
    • •
  • 6 756 tis. Kč
    • •
  • GA ČR
Project

Unusual phenomena in electronic properties of the substituted rare-earth compounds (GP202/07/P153)

This project is about to deal with intermetallics of the RTX-type with special attention to substitution on the site of transition metal atom T. In a specific. The suggested explanation consists in different mechanisms responsible f...

BM - Fyzika pevných látek a magnetismus

  • 2007 - 2009
    • •
  • 1 127 tis. Kč
    • •
  • 1 127 tis. Kč
    • •
  • GA ČR
Project

Substituted imidazopyrimidines Structure-based design and development of specific inhibitors of cancer-related protein kinases (GA19-08410S)

Deregulation of protein kinases and other signalling enzymes has been identified as an important mechanism of cellular transformation and cancer development data showed that certain imidazo[1,2-c]pyrimidine-5-ones can be substituted...

Medicinal chemistry

  • 2019 - 2021
    • •
  • 7 291 tis. Kč
    • •
  • 7 291 tis. Kč
    • •
  • GA ČR
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