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207 (0,097s) •

Project

MIcro and MAcro Connectomics of the Subthalamic nucleus in humans impact of neuromodulation and dopamine depletion (GA16-13323S)

The subthalamic nucleus (STN) is an important subcortical structure of the brain and a common target for deep brain stimulation (DBS) in the treatment of Parkinson’s disease. Despite its excellent effects on movement, STN DBS is acc...

FH - Neurologie, neurochirurgie, neurovědy

  • 2016 - 2020
    • •
  • 9 921 tis. Kč
    • •
  • 9 612 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of deep brain stimulation Role of the subthalamus in motor, visual and affective processing (GA309/09/1145)

Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is an important method of treatment for Parkinson?s disease. Though there is little doubt about the beneficial effects of STN DBS on motor functions, our knowledge of the...

FH - Neurologie, neurochirurgie, neurovědy

  • 2009 - 2012
    • •
  • 5 242 tis. Kč
    • •
  • 5 224 tis. Kč
    • •
  • GA ČR
Project

Modulation of functional connectivity of the large scale cortical networks by STN DBS (NV16-33798A)

Deep brain stimulation (DBS) is an effective long-term treatment for motor symptoms in advanced Parkinson's disease (PD). The most frequently used target is the subthalamic nucleus (STN). For some patients, the beneficial motor effe...

FH - Neurologie, neurochirurgie, neurovědy

  • 2016 - 2019
    • •
  • 8 881 tis. Kč
    • •
  • 8 881 tis. Kč
    • •
  • MZ
Project

Reducing speech-related side-effects of deep brain stimulation in Parkinson's Disease via automated speech analysis (GF21-14216L)

Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an effective treatment of motor symptoms of Parkinson’s disease (PD), but its effects on speech are equivocal. Although some aspects of speech might improve with STN-DBS...

Medical engineering

  • 2021 - 2023
    • •
  • 7 182 tis. Kč
    • •
  • 7 182 tis. Kč
    • •
  • GA ČR
Project

Clinical, Imaging and Biological predictors of effects associated with deep brain stimulation in Parkinson’s disease (NV19-04-00233)

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a common treatment for intermediate and late stages of Parkinson’s disease (PD). The development of PD is associated with the progression of several non-motor symptoms...

Clinical neurology

  • 2019 - 2023
    • •
  • 14 978 tis. Kč
    • •
  • 14 894 tis. Kč
    • •
  • MZ
Project

Subcortical nuclei and cortical functions – insight from the deep brain stimulation perspective (GA21-25953S)

Exact knowledge of the role of the subcortical nuclei and their cortical relations in physiological and pathophysiological conditions still remains insufficiently explained. Deep brain stimulation (DBS) is an established treatment for late motor symp...

Clinical neurology

  • 2021 - 2023
    • •
  • 8 656 tis. Kč
    • •
  • 8 381 tis. Kč
    • •
  • GA ČR
Project

STN-DBS outcomes in Parkinson´s disease the influence of vascular, cardiovascular, metabolic, and inflammatory co-morbidities (NU21-04-00445)

Deep brain stimulation (DBS) is an established treatment for late motor symptoms in Parkinson’s disease (PD). Although DBS is generally a successful therapy, it has limitations including insufficient clinical effects and adverse side effects. The eff...

Clinical neurology

  • 2021 - 2024
    • •
  • 11 682 tis. Kč
    • •
  • 11 682 tis. Kč
    • •
  • MZ
Project

Dynamic structure and function of the cell nucleus after irradiation (1P05OC084)

changes of structure of chromatin caused by low doses of ionizating radiation, changes of nucleus topology of chromatine...

BO - Biofyzika

  • 2005 - 2007
    • •
  • 2 522 tis. Kč
    • •
  • 1 043 tis. Kč
    • •
  • MŠMT
Project

Delivery of Polyomavirus genomes into the cell nucleus and interactions of their structural proteins in host cells (GA13-26115S)

Polyomaviruses, small tumorogenic DNA viruses replicate in the cell nucleus and mechanism of uncoating and delivery of viral genomes into the cell nucleus are still towards the cell nucleus, to reveal interactions and funct...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2013 - 2017
    • •
  • 7 539 tis. Kč
    • •
  • 7 539 tis. Kč
    • •
  • GA ČR
Project

Cooperative contribution of actin- and myosin-families to the chromatin dynamics and tranion in the cell nucleus (LH12143)

Identification of principles of collaborative action of actin-related Arp6) and myosin (NM1) proteins in functional organization of the cell nucleus and chromatin. The project aims to asses especially their contribution to the organization o...

EB - Genetika a molekulární biologie

  • 2012 - 2014
    • •
  • 3 635 tis. Kč
    • •
  • 3 635 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 207