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217 (0,054s) •

Project

Synchronization of individual circadian oscillators in suprachiasmatic nucleus (IAA5011103)

Mammalian circadian rhythms are driven by pacemaker located in suprachiasmatic nuclei (SCN). SCN consists of 10 000 cells, each of them having an independent oscillator. While in conventional cultures the dispersed SCN neurons oscillate inde...

FH - Neurologie, neurochirurgie, neurovědy

  • 2001 - 2005
    • •
  • 6 658 tis. Kč
    • •
  • 3 364 tis. Kč
    • •
  • AV ČR
Project

ADAR2-mediated RNA editing in the suprachiasmatic nucleus; focus on AMPA receptors (GA19-17037S)

of hypothalamic suprachiasmatic nuclei (SCN), which serve as a master circadian pacemaker. SCN...

Neurosciences (including psychophysiology)

  • 2019 - 2023
    • •
  • 6 041 tis. Kč
    • •
  • 6 041 tis. Kč
    • •
  • GA ČR
Project

Intracellular mechanisms of entrainment of circadian rhythm of vasopressin release from cultured suprachiasmatic neurons by VIP and melatonin. (ME 158)

Mammalian daily rhythms are driven by circadian pacemaker in suprachiasmatic nuclei (SCN) in hypothalamus. Neurons of suprachiasmatic nucleus cultured in vitro maintain the circadian rhythmicity of vasopressin release for s...

FH - Neurologie, neurochirurgie, neurovědy

  • 1998 - 2000
    • •
  • 1 124 tis. Kč
    • •
  • 679 tis. Kč
    • •
  • MŠMT
Project

Mechanism of melatonin action in suprachiasmatic nucleus (GA309/96/0682)

Pineal hormone melatonin entrains circardian rhytmus in mammals including man. It apprears to act directly through the master oscillator located in the suprachiasmatic nucleus (SCN) of hypothalamus. In our project we will study the ...

ED - Fyziologie

  • 1996 - 1998
    • •
  • 2 476 tis. Kč
    • •
  • 1 383 tis. Kč
    • •
  • GA ČR
Project

Synaptic transmission in suprachiasmatic nucleus (GA309/99/0215)

Suprachiasmatic nucleus (SCN) has been identified as a biological clock which regulates circadian and seasonal rhythms in many behavioural and physiological functions. Each of SCN neurones is apparently able to generate approximatel...

ED - Fyziologie

  • 1999 - 2001
    • •
  • 1 556 tis. Kč
    • •
  • 1 115 tis. Kč
    • •
  • GA ČR
Project

The rhythmicity of clock proteins in peripheral tissues and suprachiasmatic nucleus with respect to their subcellular location (GP309/02/D093)

In mammals, the circadian timing system is hierarchical with the main clock located in the suprachiasmatic nucleus of hypothalamus (SCN). The SCN are entrained to the 24 hr day predominantly by the daily light-dark cycle and, in tur...

ED - Fyziologie

  • 2002 - 2005
    • •
  • 742 tis. Kč
    • •
  • 742 tis. Kč
    • •
  • GA ČR
Project

Glutamate receptors expression within the rat suprachiasmatic nuclei, the circadian regulation and receptor subunits function in the circadian clock e (GAP303/10/1227)

Mammalian biological clock located in the suprachiasmatic nuclei of the hypothalamus (SCN), is entrained by light, which affects the SCN neurons via glutamatergic synapses of retinohypothalamic tract. The effect of light or glutamate on the ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2012
    • •
  • 2 481 tis. Kč
    • •
  • 2 481 tis. Kč
    • •
  • GA ČR
Project

Light entrainment of the molecular core clock mechanism in the rat suprachiasmatic nucleus (IAA5011304)

In mammals, principal circadian pacemaker is located in the suprachiasmatic nuclei (SCN) which consist of two parts, the ventrolateral (VL-) and the dorsomedial (DM-). The molecular core clock mechanism involves interacting positive and nega...

ED - Fyziologie

  • 2003 - 2005
    • •
  • 2 366 tis. Kč
    • •
  • 1 633 tis. Kč
    • •
  • AV ČR
Project

Purinergic P2X receptors and their role in suprachiasmatic nuclei of hypothalamus (IAA500110702)

of P2XRs in suprachiasmatic nuclei (SCN), extracellular ATP metabolism and the role...

ED - Fyziologie

  • 2007 - 2009
    • •
  • 1 863 tis. Kč
    • •
  • 1 863 tis. Kč
    • •
  • AV ČR
Project

Intracellular mechanisms of entrainment of the circadian pacemaker in hypothalamic suprachiasmatic nucleus (GA309/99/0213)

We intend to study molecular mechanisms of entrainment of the circadian pacemaker in suprachiasmatic nuclei (SCN) in hypothalamus. Circadian rhythms of vasopressin (AVP) and vasoactive intestinal peptide (VIP) release from dispersed SCN neur...

FH - Neurologie, neurochirurgie, neurovědy

  • 1999 - 2001
    • •
  • 2 600 tis. Kč
    • •
  • 2 110 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 217