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99 (0,116s) •

Project

Callose synthases - dynamics and mechanisms of secretion. (GA18-12579S)

Callose synthases are transmembrane enzymes producing callose (β-1,3-glucan synthase paralogs, acting in different tissues and processes. So far, most for their function. In our previous project, we showed that callose synthase<...

Plant sciences, botany

  • 2018 - 2023
    • •
  • 4 949 tis. Kč
    • •
  • 4 949 tis. Kč
    • •
  • GA ČR
Project

DAPIT protein and its role in biogenesis of mitochondrial ATP synthase (GA16-01813S)

FoF1-ATP synthase composed of 15 core structural subunits is the key enzyme of this novel protein for biogenesis of ATP synthase, its structural properties, lipid synthase energetics, we will also test possible involvement ...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 6 121 tis. Kč
    • •
  • 5 839 tis. Kč
    • •
  • GA ČR
Project

Aspects of proteomics of chalcone synthases and chalcone synthase-like proteins in hop important for lupulin biosynthesis (GP521/06/P323)

the enzyme activities of chalcone synthases and chalcone synthase-like proteins, which members of hop chalcone synthase gene family, which were detected in hop genome......

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 1 200 tis. Kč
    • •
  • 1 200 tis. Kč
    • •
  • GA ČR
Project

Computational and Experimental Characterization of Enzymes for Sustainable Design of Bioplastics (GM25-17459M)

depolymerases exists, its counterpart summarizing knowledge of PHA synthases is missing a novel classification of PHA synthases. Moreover, we will experimentally characterize in vitro and in vivo experiments to describe the propert...

Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

  • 2025 - 2029
    • •
  • 24 955 tis. Kč
    • •
  • 24 955 tis. Kč
    • •
  • GA ČR
Project

Mechanism of ATP synthase biogenesis and the role of TMEM70 protein (GAP303/11/0970)

ATP synthase is the key enzyme of mitochondrial energy provision, responsible that are assembled into a functional ATP synthase in a stepwise process that depends on several helper proteins. Recently we have discovered a new type of...

CE - Biochemie

  • 2011 - 2015
    • •
  • 8 963 tis. Kč
    • •
  • 8 963 tis. Kč
    • •
  • GA ČR
Project

Supramolecular organization of mitochondrial ATP synthase in metabolic regulations (GA17-08565S)

Oligomers of mitochondrial ATP-synthase form cristae edges and determine cristae morphology in relation to metabolism. This relationship will be elucidated antibodies against ATP-synthase subunits; or by homo-FRET (energy transfer b...

EA - Morfologické obory a cytologie

  • 2017 - 2019
    • •
  • 6 594 tis. Kč
    • •
  • 6 462 tis. Kč
    • •
  • GA ČR
Project

Structure of the Promoter and the 5-untranslated region of the Human Cystathionine Synthase Gene. (IZ3963)

Isolation,sequencing,and functional analysis of the promoter and the 5 -untranslated region of the human gene for cystathionine synthase is proposed.Possible defects in this gene expression will be correlated with specific diseases.......

FG - Pediatrie

  • 1997 - 1999
    • •
  • 676 tis. Kč
    • •
  • 676 tis. Kč
    • •
  • MZ
Project

The modulating influence of NO in the signal pathways controlling hormonal secretion, in the development of experimental diabetes and protein glycation (GA311/98/P089)

inhibit iodine organification and the growth of thyrocytes in vitro. The NO-synthase regulation pathways. We will study the influence of NO-synthase inhibitionon, the changes of hypophyseal dopaminergic system during the NO-syn...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2000
    • •
  • 932 tis. Kč
    • •
  • 624 tis. Kč
    • •
  • GA ČR
Project

New factors regulating biogenesis of subunit c from mammalian FoF1 ATP synthase (GA20-25768S)

Mitochondrial F1Fo ATP synthase is the key enzyme of energy provision in most eukaryotic organisms. While its catalytic F1 domain is conserved throughout evolution to interact with subunit c. Of those, TMEM70 is already identified ATP sy...

Cell biology

  • 2020 - 2023
    • •
  • 6 786 tis. Kč
    • •
  • 6 786 tis. Kč
    • •
  • GA ČR
Project

Trangenic and pharmacological complementation of inherited ATP synthase disorders (NV16-33018A)

Inborn deficiency of ATP synthase, the key enzyme of cellular energy provision, belongs to the most severe metabolic diseases. The prevailing cause of this disease as it is not absolutely essential for ATP synthase biogenesis and su...

FG - Pediatrie

  • 2016 - 2019
    • •
  • 14 567 tis. Kč
    • •
  • 14 567 tis. Kč
    • •
  • MZ
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