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1 392 (0,088s) •

Project

Advanced stimuli-responsive giant vesicles – towards the mimicking of essential cell functions (LUAUS24137)

. Specifically, giant unilamellar vesicles (GUVs) have gained popularity in bottom-up synthetic biology. GUVs can be produced from lipids and/or amphiphilic block copolymers and cell biology. Their bilayer can be engineer...

Analytical chemistry

  • 2024 - 2027
    • •
  • 6 755 tis. Kč
    • •
  • 6 755 tis. Kč
    • •
  • MŠMT
Project

Bridging Borders in Membrane Science A Multinational Study on Synthetic Lipid Systems and Vesicles (8X25020)

The goal is to improve the understanding of the behavior and mutual interactions in different environments and under different conditions of synthetic phospholipid membranes and their associated vesicular systems using state-of-the-art bioph...

Other biological topics

  • 2025 - 2027
    • •
  • 244 tis. Kč
    • •
  • 244 tis. Kč
    • •
  • MŠMT
Project

New metabolic pathways of lipid trafficking (LUAUS24040)

the composition of lipid cargo directed to extracellular vesicles by labeling lipids in endothelial cells. 2. Cyclic metabolic pathways of neutral lipids 2.1 Quantify the rate quantitative analysis of intra- and i...

Biochemistry and molecular biology

  • 2024 - 2027
    • •
  • 10 122 tis. Kč
    • •
  • 10 122 tis. Kč
    • •
  • MŠMT
Project

Understanding cell compartment and liquid phase restricted functions of Dishevelled (GA22-25365S)

The project will address how Dishevelled (DVL), the key signaling regulator in the Wnt pathway, achieves its multitude of functions. The basis of the project will be the focus on the biochemistry of the purified full length DVL3. We will address the ...

Cell biology

  • 2022 - 2024
    • •
  • 13 338 tis. Kč
    • •
  • 13 326 tis. Kč
    • •
  • GA ČR
Project

Peptide Killers of Bacteria (LL2007)

We will develop a method for the targeting of peptides to membranes with specific lipid composition and determine key peptide properties for membrane translocation and pore formation. The designed peptides will be experimentally tested on

Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect)

  • 2020 - 2021
    • •
  • 13 476 tis. Kč
    • •
  • 13 476 tis. Kč
    • •
  • MŠMT
Project

Bottom-up unraveling of biophysical determinants of ORP5/8 mediated lipid transport using in vitro reconstitution and model membranes (GA19-18917S)

Membrane homeostasis requires organized transport of lipids from (ORPs) represent a family of lipid transfer proteins, two members of which, ORP5/8 cargo lipids are exchanged for one another. Yet, the biophysical understand...

Biochemistry and molecular biology

  • 2019 - 2021
    • •
  • 3 705 tis. Kč
    • •
  • 3 705 tis. Kč
    • •
  • GA ČR
Project

The plasticity of protein-lipid interfaces in plant membranes perceived through evolutionary lenses (GA22-35916S)

about the crosstalk and evolutionary dynamics between membrane lipids and peripheral experiments that use the vesicle tethering complex exocyst as a model for the protein-lipid continuum. This project will shed new light o...

Cell biology

  • 2022 - 2024
    • •
  • 6 688 tis. Kč
    • •
  • 6 688 tis. Kč
    • •
  • GA ČR
Project

In vitro reconstitution of viral “Replication factories“ (GJ15-21030Y)

The main marker of the Golgi and the trans-Golgi network (TGN) – phosphatidyl inositol 4-phosphate (PI4P) - is synthesized by the action of PI4 kinases (PI4Ks) that play key roles in lipid synthesis and cellular trafficking. Furthermore, PI4...

CE - Biochemie

  • 2015 - 2017
    • •
  • 5 551 tis. Kč
    • •
  • 5 551 tis. Kč
    • •
  • GA ČR
Project

SIGNALS - The role of anionic phospholipids in the regulation of endocytosis in tip-growing plant cells (8J19AT004)

membrane phospholipids in the initiation and formation of clathrin-coated vesicles is the spatio-temporal dynamics of anionic lipids and clathrin-endocytic machinery in tip anionic lipids affects the initiation and progres...

Plant sciences, botany

  • 2019 - 2020
    • •
  • 122 tis. Kč
    • •
  • 122 tis. Kč
    • •
  • MŠMT
Project

Peptides controlling membrane curvature (LUC25012)

The project focuses on lipid membrane curvature and peptides that are sensitive to curvature or capable of modulating curvature. Membrane curvature plays a crucial role in many physiological cellular processes, such as endocytosis, exocytosi...

Biophysics

  • 2025 - 2027
    • •
  • 4 689 tis. Kč
    • •
  • 4 689 tis. Kč
    • •
  • MŠMT
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