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5 165 (0,135s) •

Project

Exploration of the TPP riboswitch as a new target for antibiotics (8F19007)

1. Explore the TPP riboswitch as a target for antibiotics, in particular for key ESKAPE pathogens and Streptococcus pneumoniae 2. Develop an HTS-compatible assay to monitor TPP riboswitch transcription regulation 3. Conduct an HTS f...

Microbiology

  • 2019 - 2023
    • •
  • 2 333 tis. Kč
    • •
  • 2 333 tis. Kč
    • •
  • MŠMT
Project

Self-smoothing effect of double-pulse-laser plasma (GA202/96/1688)

exploration of the physical processes which are responsible for the smoothing the fluctuationsin the target intensity distribution is planned. The effectiveness of laser-target coupling in the presence of the prepulse plas...

BL - Fyzika plasmatu a výboje v plynech

  • 1996 - 1998
    • •
  • 1 741 tis. Kč
    • •
  • 685 tis. Kč
    • •
  • GA ČR
Project

Dual FLT3/CDK9 inhibition as a possible therapeutical approach for mixed lineage leukemia (GA19-09086S)

oncogenic MLL and FLT3. In this project we intend to explore dual FLT3/CDK9 targeting regulators including CDK9 on target gene loci. Besides that, MLL-rearranged leukemias into heterobifunctional proteolysis targeting<...

Oncology

  • 2019 - 2023
    • •
  • 9 576 tis. Kč
    • •
  • 9 576 tis. Kč
    • •
  • GA ČR
Project

Restoring Motor Functions in Parkinson’s Disease with Noninvasive Hybrid Transcranial Neuromodulation (8F21003)

(TIF) to target GPi of PD patients; (2) Using LIFUS to target the STN, substantia; (4) Exploring additive neuromodulator effects of transcranial US stimulation and safety margins, and exploring avenues for sensiti...

Other medical science

  • 2021 - 2023
    • •
  • 8 870 tis. Kč
    • •
  • 8 764 tis. Kč
    • •
  • MŠMT
Project

Targeting of cytokinin oxidase and its role in regulation of plant development (GA206/02/0967)

in transformed plant cells, we propose here to explore modulated down-regulation of cytokinins by control of expression and targeting of cytokinin oxidase (CKX3). CKX3 or lacking functional target domain targeting...

EF - Botanika

  • 2002 - 2004
    • •
  • 6 532 tis. Kč
    • •
  • 2 427 tis. Kč
    • •
  • GA ČR
Project

Mechanistic studies on dual targeting of DNA and histone deacetylase with bifunctional inhibitors (GA14-21053S)

are to explore novel approaches to drug targeting and delivery, specifically to the nucleus capable of dual targeting of histone deacetylase and DNA, the cytotoxicity, selective targeting to cancer cells, DNA bind...

CE - Biochemie

  • 2014 - 2016
    • •
  • 5 599 tis. Kč
    • •
  • 5 599 tis. Kč
    • •
  • GA ČR
Project

Advanced photocatalytic materials for water splitting and their rational design (GA17-12800S)

Project aims at targeted preparation of advanced photocatalytic materials for photo(electro)catalytic generation of hydrogen and advanced oxidative processes. Targeted preparation of the novel oxides will explore anisotropy...

CG - Elektrochemie

  • 2017 - 2019
    • •
  • 4 401 tis. Kč
    • •
  • 3 867 tis. Kč
    • •
  • GA ČR
Project

Development of new, targeting polynuclear platinum and ruthenium complexes for anticancer chemotherapy. Mechanism of action (GC20-14082J)

new, targeting polynuclear platinum and ruthenium-based agents that circumvent and cellular targeting; (ii) to enhance our knowledge of the molecular and cellular level complexes of platinum group metals. The secondary objective is...

Medicinal chemistry

  • 2020 - 2022
    • •
  • 6 513 tis. Kč
    • •
  • 6 432 tis. Kč
    • •
  • GA ČR
Project

T-MAPs High content mapping of surface molecules in normal and disturbed development T lymphocytes, a search for diagnostic and therapeutic targets (NU20-05-00282)

interaction and thus are important targets of therapeutic interventions. At the same time subsets, a “T-MAP”. It will be shared on HCDM website. Next, we will explore their utility as therapy targets, diagnostic target...

Immunology

  • 2020 - 2023
    • •
  • 9 118 tis. Kč
    • •
  • 9 118 tis. Kč
    • •
  • MZ
Project

Targeting oncogenic kinases with small molecules (GA21-06553S)

There are numerous cancer types, which still await selective and targeted drugs. This project is focused on development of novel small molecule inhibitors of protein kinases based on less explored imidazopyridine, pteridine and pyra...

Medicinal chemistry

  • 2021 - 2024
    • •
  • 6 487 tis. Kč
    • •
  • 6 487 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 5 165