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Development of method for membrane protein target identification of biologically active small molecules (GA23-05642S)
identification of small molecule targets and their regulatory pathways.Phenotypic screening often yields hit molecules with an unknown modes of action. For further development of these hits, it is necessary to identify the...
Polymer science
- 2023 - 2025 •
- 8 931 tis. Kč •
- 8 706 tis. Kč •
- GA ČR
Řešení projektu: 1. 3. 2023 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (97%)
Poskytovatel: Grantová agentura České republiky
T-MAPs High content mapping of surface molecules in normal and disturbed development T lymphocytes, a search for diagnostic and therapeutic targets (NU20-05-00282)
Surface molecules on T-lymphocytes are crucial structures for cell-cell interaction and thus are important targets of therapeutic interventions. At the same time their utility as therapy targets, diagnostic targets...
Immunology
- 2020 - 2023 •
- 9 118 tis. Kč •
- 9 118 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2020 - 31. 12. 2023
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
The concept of rationally designed triple agents against Alzheimer's disease (GA22-24384S)
of the disease. Thus, a new group of potential drugs called multi-target directed ligands due to random selection of biological targets. In the proposed project, we will validate the concept of MTDLs with a rationally designed seri...
Pharmacology and pharmacy
- 2022 - 2024 •
- 11 378 tis. Kč •
- 11 378 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2022 - 31. 12. 2024
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Development of Novel Ribosome-Targeting Antibiotics (8F19006)
The overall objective is to identify, characterize and optimize molecules as novel lead compounds for the development of novel antimicrobial agents targeting translation.......
Microbiology
- 2019 - 2022 •
- 5 836 tis. Kč •
- 5 836 tis. Kč •
- MŠMT
Řešení projektu: 1. 4. 2019 - 30. 9. 2022
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Triterpenoid acids in supramolecular chemical biology (LD15012)
of the target compounds, and will contribute to the ability of the target molecules to self of the target molecules with hydrophilic oligopeptides, namely those of the RGD type which the ability of the
CC - Organická chemie
- 2015 - 2017 •
- 1 665 tis. Kč •
- 1 665 tis. Kč •
- MŠMT
Řešení projektu: 7. 10. 2015 - 31. 12. 2017
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Development and characterization of small molecules modulating activity of DNA-PK (GA25-17299S)
Small molecules targeting DNA repair may sensitize tumors to radiotherapy in human cells. Therefore, DNA-PK is a promising pharmacological target for tumor therapy. While most efforts have focused on targeting DNA-...
Biochemistry and molecular biology
- 2025 - 2027 •
- 10 224 tis. Kč •
- 10 053 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2025 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (98%)
Poskytovatel: Grantová agentura České republiky
Electronic and resonant excitation as a trigger of molecular dissociation dynamics and energy transfer (LTAUSA19031)
The aim of the project is to characterize the dissociative dynamics in molecules triggered by the low-energy electron impact. The special focus is on the effect of microhydration of target molecules on the dissociation dyna...
Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect)
- 2020 - 2023 •
- 3 437 tis. Kč •
- 3 437 tis. Kč •
- MŠMT
Řešení projektu: 1. 1. 2020 - 31. 12. 2023
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Targeting oncogenic kinases with small molecules (GA21-06553S)
There are numerous cancer types, which still await selective and targeted drugs. This project is focused on development of novel small molecule inhibitors of protein kinases based on less explored imidazopyridine, pteridine and pyra...
Medicinal chemistry
- 2021 - 2024 •
- 6 487 tis. Kč •
- 6 487 tis. Kč •
- GA ČR
Řešení projektu: 1. 4. 2021 - 31. 3. 2024
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Peptide Drug Delivery Systems Targeting Macrophages for Antimycobacterial Active Compounds (GJ17-27514Y)
The project is focused on the development of novel macrophage-targeting drug with established, modified or novel antimycobacterial molecules. The structure of peptide via various linkers. Oligotuftsin carriers that target s...
FR - Farmakologie a lékárnická chemie
- 2017 - 2019 •
- 4 525 tis. Kč •
- 4 525 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2017 - 31. 12. 2019
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Nanostructured inorganic materials based on molecular sieves for sensor application (GA203/05/2309)
-alumophosphates with target molecules (as NO, NO2, N2O, O2, NH3, H2O, CO, various organic insight into interatomic interactions between target molecules and TM of the interactiontarget molecule - TM ion a...
CF - Fyzikální chemie a teoretická chemie
- 2005 - 2007 •
- 1 965 tis. Kč •
- 1 965 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2005 - 31. 12. 2007
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
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