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39 (0,116s) •

Project

Tau in Central Nervous System neurotoxic and autoimmune component (GA13-26601S)

Tau, natively soluble protein with minimal secondary structure can undergo is Alzheimer disease (AD). It is assumed now that altered soluble tau species are the main vehicles of tau pathology. We will inject rats intracereb...

FH - Neurologie, neurochirurgie, neurovědy

  • 2013 - 2018
    • •
  • 5 085 tis. Kč
    • •
  • 5 085 tis. Kč
    • •
  • GA ČR
Project

Investigating the effects of tau mutations on the activity of VQIVYK-targeting agents on tau seeding in neurodegenerative diseases (GC23-06301J)

, are a group of neurological disorders characterised by intracellular deposits of tau aggregates. Evidence suggests that pathogenic tau develops early in patients' brains in inhibitors targeting the VQIINK or VQIVYK motifs in t...

Cell biology

  • 2023 - 2025
    • •
  • 7 776 tis. Kč
    • •
  • 7 776 tis. Kč
    • •
  • GA ČR
Project

In-situ structural architecture and cellular interactions of Tau neurofibrils (GN22-15175I)

Neurofibrillary tangles are formed of misfolded, pathologically altered Tau protein. Tau pathology spreads between neurons and propagates misfolding in a prion disease (AD). Despite the advancements in our understanding of Tau

Cell biology

  • 2022 - 2024
    • •
  • 5 833 tis. Kč
    • •
  • 5 833 tis. Kč
    • •
  • GA ČR
Project

Mitochondrial toxicity of tau protein oligomers and its regulation by drugs for Alzheimer's disease (NU23-04-00032)

tau protein (tau) oligomers, and mitochondrial dysfunction, are currently being dysfunction caused by soluble tau oligomers in isolated brain mitochondria and subsequent and their combinations against mitochondrial dysfunc...

Neurosciences (including psychophysiology)

  • 2023 - 2026
    • •
  • 6 533 tis. Kč
    • •
  • 6 533 tis. Kč
    • •
  • MZ
Project

Label-free super-resolution microscopy based on single-protein fluctuations to study the assembly of tau protein envelopes (GA23-07703S)

In neuronal cells, tau proteins regulate the access of other protein to microtubules. Pathological self-assembly of tau is a hallmark of a several processes including the earliest stages of the tau aggregate formation. To c...

Cell biology

  • 2023 - 2025
    • •
  • 9 981 tis. Kč
    • •
  • 9 981 tis. Kč
    • •
  • GA ČR
Project

Involvement of Tau in neuronal functions of ghrelin a new target for Alzheimer''s disease? (7AMB12FR011)

In this project, we propose to study the effects of ghrelin agonist and antagonists, synthesized in the Institute of Organic Chemistry and Biochemistry (the Czech team) that are potential anti-obesity compounds, on : 1- Tau phosphorylation, ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2012 - 2013
    • •
  • 124 tis. Kč
    • •
  • 124 tis. Kč
    • •
  • MŠMT
Project

Selective NMR labelling as a tool for characterization of protein complexes involved in neurodegenerative diseases. (LTAUSA18168)

The aim of the project is implementation of methodology of solution fluorine 19F NMR for study of tau and Map2c proteins and its utilization in three areas: 1 Tau and Map2c proteins and their binding partners – 14 3 3 protein and SH...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 6 620 tis. Kč
    • •
  • 6 620 tis. Kč
    • •
  • MŠMT
Project

Diagnosis of Alzheimer disease based on detections of complexes of amyloid beta peptide and of some endogenous substances in cerebrospinal fluid (NT11225)

dehydrogenase type 10 or protein tau in cerebrospinal fluids of demented and nondemented, total tau and phospho-tau levels by means of kits).......

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2013
    • •
  • 9 657 tis. Kč
    • •
  • 9 657 tis. Kč
    • •
  • MZ
Project

Interactions of intracellular amyloid beta and diagnosis of Alzheimer disease (NV16-27611A)

binding targets (protein tau, mitochondrial enzymes 17beta-hydroxysteroid with the current biomarkers (amyloid beta 1-42, tau and phospho-tau) and with the degree......

FH - Neurologie, neurochirurgie, neurovědy

  • 2016 - 2019
    • •
  • 12 342 tis. Kč
    • •
  • 12 342 tis. Kč
    • •
  • MZ
Project

Effect of different types of antidiabetic interventions on the development of neurodegenerative changes in brain of diabetic mice (GAP303/12/0576)

phosphorylation of Tau protein and/or formation of Amyloid beta peptide (Abeta) plaques hyperphosphorylation of Tau protein and insulin signaling will broaden this piece of knowledge. In the hippocampus and brain cortex of diabetic...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2014
    • •
  • 8 919 tis. Kč
    • •
  • 8 919 tis. Kč
    • •
  • GA ČR
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