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212 (0,117s) •

Project

Telomere homeostasis from colorectal adenoma to metastatic cancer. (GA21-27902S)

Altered DNA repair mechanisms and disrupted telomere length homeostasis are prerequisites of cancer initiation. Supposedly, telomere length maintenance changes throughout the cancer continuum. A telomere-driven cri...

Oncology

  • 2021 - 2024
    • •
  • 12 958 tis. Kč
    • •
  • 12 958 tis. Kč
    • •
  • GA ČR
Project

Evolution of genomic instability and disruption of telomere integrity in colorectal cancer (NU22J-03-00028)

of CIN phenotype are not currently well characterized, impaired telomere homeostasis of various intracellular and extracellular factors. Disrupted telomere homeostasis may repair, a mechanism causing MSI phenotype...

Oncology

  • 2022 - 2025
    • •
  • 5 828 tis. Kč
    • •
  • 5 828 tis. Kč
    • •
  • MZ
Project

Telomere homeostasis as potential biomarker of risk, prognosis and progression in gynaecologic tumours. (NU21-03-00145)

Disruption of telomere length (TL) homeostasis in lymphocytes has been at the determination of the telomere homeostasis dynamic in onset and progression of gynaecological on telomere homeostasis i...

Oncology

  • 2021 - 2024
    • •
  • 10 438 tis. Kč
    • •
  • 10 438 tis. Kč
    • •
  • MZ
Project

Characterization of telomer chromatin proteins (IAC5004111)

complexes of telomeres. The project is focused on characterization of previously detected 40 kDa telomere-binding protein, its purification and partial sequencing. Besides, characterization of telomeric chromatin, namely t...

CE - Biochemie

  • 2001 - 2001
    • •
  • 344 tis. Kč
    • •
  • 207 tis. Kč
    • •
  • AV ČR
Project

The role of ATF2 transcription factor in development and homeostasis of colon and its involvement in progression of colorectal carcinoma (LTAB19002)

1) Characterisation of lethal phenotype in ATF2 KO mouse model 2) Mapping of ATF2 expression during development and in adult tissues 3) Distinguishing tissue specific roles (Inducible Knock out startegy) 4) Molecular context of ATF2 in intestine d...

Genetics and heredity (medical genetics to be 3)

  • 2019 - 2021
    • •
  • 1 200 tis. Kč
    • •
  • 1 200 tis. Kč
    • •
  • MŠMT
Project

Physiological role of cation/proton antiporters in monovalent cation homeostasis, Ca2+ signalling and intracellular pH regulation (GA17-01953S)

The tight regulation of intracellular ion concentrations is crucial for all cells. Optimal levels of cations are ensured by the coordinated activity of various transporters. If the activity of ion transporters and consequently ion homeostasis

EE - Mikrobiologie, virologie

  • 2017 - 2019
    • •
  • 5 032 tis. Kč
    • •
  • 4 762 tis. Kč
    • •
  • GA ČR
Project

Establishment and regulation of auxin homeostasis on a single cell level Metabolic and transport processes (GA16-10948S)

contributing to the establishment and modulation of homeostasis of plant growth regulatory will design a mathematical model of control of auxin homeostasis on a single cell level homeostasis on a single cell level under va...

ED - Fyziologie

  • 2016 - 2018
    • •
  • 8 152 tis. Kč
    • •
  • 7 861 tis. Kč
    • •
  • GA ČR
Project

Transport systems involved in intracellular pH homeostasis and yeast tolerance to low external pH (LTC20006)

and pH homeostasis in yeast cells. Further, new knowledge will help to identify transporters whose engineering may improve the robustness of intracellular pH homeostasis......

Microbiology

  • 2020 - 2023
    • •
  • 4 326 tis. Kč
    • •
  • 4 326 tis. Kč
    • •
  • MŠMT
Project

Molecular pathophysiology of selected congenital disorders of erythropoiesis (NT13587)

A. Molecular-genetic diagnosis of hemoglobinopathies in Czech population with focus on beta-thalassemic syndromes. B. Cellular and molecular-genetic analysis of selected cases with congenital microcytic anemia due to disrupted iron homeostasis

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 8 087 tis. Kč
    • •
  • 8 087 tis. Kč
    • •
  • MZ
Project

An expanded view of energy homeostasis neural integration of insulin and adipokinetic hormone signalling (EF18_070/0008772)

The project target is to support quality research worker who succeeded with his project within H2020-MSCA-IF but has not been choosen for financing due to lack of financial resources. The project supported in such a way should therefore enable the re...

Biochemistry and molecular biology

  • 2019 - 2021
    • •
  • 2 449 tis. Kč
    • •
  • 2 449 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 212