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48 (0,155s) •

Project

Interaction partners of plant telomeres and telomerases (LH13052)

by telomerase. Creation of functional model of plant telomerase interactome is neccessary nontelomericfunctions of telomerase. Determination of interaction between telomere structure and telomerase via identificat...

EB - Genetika a molekulární biologie

  • 2013 - 2015
    • •
  • 1 751 tis. Kč
    • •
  • 1 751 tis. Kč
    • •
  • MŠMT
Project

Telomeres and telomerase transition from molecular to structural biology approach. (IAA500040801)

by the specific nucleoprotein complex of telomerase. Telomerase also participates in healing of chromosome breaks by adding telomeric sequences de novo. Telomerase in plant cells proliferation status. Therefore, plant ...

EB - Genetika a molekulární biologie

  • 2008 - 2012
    • •
  • 5 710 tis. Kč
    • •
  • 5 710 tis. Kč
    • •
  • AV ČR
Project

Involvement of telomerase in the cell interactome (GA18-07027S)

recently proteins that may function as interaction partners of plant telomerase in vivo. We aim to elucidate their functional relationship with Arabidopsis telomerase encoding these proteins and of their telomerase-indepen...

Plant sciences, botany

  • 2018 - 2021
    • •
  • 12 531 tis. Kč
    • •
  • 11 628 tis. Kč
    • •
  • GA ČR
Project

Biogenesis and evolution of telomerase in plants (GX20-01331X)

other things, with the observations of: i) reversible regulation of telomerase. The answer is presumably hidden in the most important telomere factor – the telomerase. Recently we identified templating telomerase RNA subun...

GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming

  • 2020 - 2024
    • •
  • 48 597 tis. Kč
    • •
  • 48 597 tis. Kč
    • •
  • GA ČR
Project

Analysis of telomerase activity in benign and malignant breast lesions (NM17)

The telemerase activity will be analyzed in tissue of primary breast cancer,in phylloid tumors,and in various non-cancerous lesions of breast(fibroadenoma,dysplastic tissue,fibrocystic disease)by means of Telomerase PCR ELISA method. Knowled...

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 1 505 tis. Kč
    • •
  • 1 294 tis. Kč
    • •
  • MZ
Project

The molecular mechanism of telomerase inhibition targeted defeat of cancer cell proliferation (GA16-20255S)

proliferate. Telomeric DNA extension by telomerase thus contributes to the immortalization the mechanism of telomerase action at telomeres and then to test new ways to inhibit the dynamics and kinetics of critical interactions of h...

BO - Biofyzika

  • 2016 - 2018
    • •
  • 7 569 tis. Kč
    • •
  • 6 840 tis. Kč
    • •
  • GA ČR
Project

Molecular evolution and functional analysis of components of plant telomeres and telomerases (GA521/05/0055)

degradation and fusions. Many organisms use telomerase, comprising telomere reverse transcriptase (TERT) and telomerase RNA (TR), to replenish ends of chromosomal DNA lost and telomerase evolution and function of component...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 3 792 tis. Kč
    • •
  • 3 792 tis. Kč
    • •
  • GA ČR
Project

The Dynamic World of Telomeres Unraveling Evolutionary Innovations in Genome Stability (GA25-15566S)

and their maintenance mechanisms, compare telomerase-dependent and -independent lengthening pathways and their phylogenetic distribution. We will identify new components of telomeres, telomerases, and telomerase-independen...

Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

  • 2025 - 2028
    • •
  • 12 829 tis. Kč
    • •
  • 12 829 tis. Kč
    • •
  • GA ČR
Project

Telomerase activity as a novel prognostic factor in multiple myeloma (NC7043)

Telomerase assay in multiple myeloma is new perspective prognostic factor in multiple myeloma The use od hTERT as tumor antigen is promising new treatment modality and could circumvent limitation of current vaccination protocols in multiple ...

EC - Imunologie

  • 2002 - 2004
    • •
  • 2 700 tis. Kč
    • •
  • 2 615 tis. Kč
    • •
  • MZ
Project

Telomere study at selected types of malignancies by in situ techniques (GA204/00/P012)

telomerase. In most somatic cells, telomerase is not active, and telomeres shorten. This has been supposed to be accomplished by the reactivation of the telomerase,but tumor samples negatîve for telomerase with no...

EB - Genetika a molekulární biologie

  • 2000 - 2002
    • •
  • 219 tis. Kč
    • •
  • 219 tis. Kč
    • •
  • GA ČR
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