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5 349 (0,127s) •

Project

Tick microRNAs as modulators of vertebrate host physiology (LUABA22020)

Aim 1: Localization and quantification of miRNAs in Ixodes ricinus ticks Aim 2: Cloning of tick miRNA targets and study of the effect of miRNA on mammalian cells Aim 3: Transcriptomic analysis of host gene modulation up...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 1 199 tis. Kč
    • •
  • 1 199 tis. Kč
    • •
  • MŠMT
Project

The functional characterization of tick salivary immunomodulators belonging to the Iristatin family (GA19-07247S)

research program leverages our expertise in tick-host interactions to perform in silico modulate vertebrate host response at the tick-host interface to facilitate arthropod feeding by regulating ...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 11 674 tis. Kč
    • •
  • 11 380 tis. Kč
    • •
  • GA ČR
Project

Centre for molecular ecology of vectors and pathogens (LC06009)

education of young parasitologists. Molecular interactions significant for transmission of pathogen will be studied on the models tick ? Borrelia, phlebotomus ? Leishmania and trematode ? snail. Immune interaction vector ?...

EG - Zoologie

  • 2006 - 2011
    • •
  • 81 487 tis. Kč
    • •
  • 78 475 tis. Kč
    • •
  • MŠMT
Project

Flavivirus-host interactions on the transcriptional and translational level (LTAUSA18040)

The proposed project is aimed at description of interaction between the tick-borne encephalitis virus and other flaviviruse with host cells on the level of transciption and translation and description of the effects of infe...

Genetics and heredity (medical genetics to be 3)

  • 2019 - 2022
    • •
  • 8 734 tis. Kč
    • •
  • 8 734 tis. Kč
    • •
  • MŠMT
Project

Investigating the role of tick salivary protease inhibitors at the interface between ticks, pathogens and the vertebrate host (GAP502/12/2409)

Ticks transmit the most commonly reported vector-borne diseases in the northern hemisphere. Upon pathogen transmission, tick salivary protease inhibitors play a role in mitigating the hosts immune response. How salivary pro...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 11 756 tis. Kč
    • •
  • 8 956 tis. Kč
    • •
  • GA ČR
Project

Serpins from the salivary glands of Lyme disease vector, the tick Ixodes ricinus, and their role in the tick-host-pathogen interaction (GJ16-07117Y)

of ixodid ticks contains hundreds of different proteins that interfere with all types of host defensive mechanisms. Tick salivary protease inhibitors, serpins, were shown. ricinus salivary serpins, in order to better under...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 5 616 tis. Kč
    • •
  • 5 616 tis. Kč
    • •
  • GA ČR
Project

Structural proteomics of proteolytic systems in ticks (GAP207/10/2183)

The proteolytic systems of parasitic ticks are critical for effective interaction with the host. This project is focused on (i) protease inhibitors from tick saliva that suppress host defenses, and (ii) pr...

CE - Biochemie

  • 2010 - 2013
    • •
  • 4 994 tis. Kč
    • •
  • 4 994 tis. Kč
    • •
  • GA ČR
Project

Functional characterization of cytokine binding molecules from tick saliva (GN23-07242I)

of host defense mechanisms. Our hypothesis based on data from other tick species binding proteins in their saliva. These molecules can protect ticks from host immune transmission from ticks to their h...

Biochemistry and molecular biology

  • 2023 - 2026
    • •
  • 5 916 tis. Kč
    • •
  • 5 916 tis. Kč
    • •
  • GA ČR
Project

Effect of tick saliva on the transmission of Borrelia burgdorferi (GA524/02/0901)

Tick saliva, due to its anti-haemostatic, vasodilatory and immunomodulatory effects, facilitate not only tick feeding on the host, but also transmission of tick-borne pathogens. The general effect of tick ...

EC - Imunologie

  • 2002 - 2004
    • •
  • 3 340 tis. Kč
    • •
  • 2 540 tis. Kč
    • •
  • GA ČR
Project

The effect of tick salivary molecules on replication of tick-borne encephalitis virus in innate immunity cells (GA14-25799S)

, and identification of proteins interacting with tick cystatins will be performed. ThroughTick-borne encephalitis virus (TBEV) is transmitted to humans by infected ticks and can cause severe encephalitis. Transmis...

EC - Imunologie

  • 2014 - 2016
    • •
  • 5 904 tis. Kč
    • •
  • 5 904 tis. Kč
    • •
  • GA ČR
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