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3 022 (0,175s) •

Project

Influence of Toll-like Receptor Agonists on Immunogenicity of Tumour Cells in B cell Chronic Lymphocytic Leukemia (GP310/08/P353)

approaches to this disease. Non-malignant B cells express broad spectrum of Toll-like receptors, evolutionarily conserved proteins that recognize microbial molecules and initiate host defence. Some of their agonists

EC - Imunologie

  • 2008 - 2010
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • GA ČR
Project

Polymer vaccines novel high potent immunostimulants for infectious disseases treatment (GJ16-14957Y)

of the immunostimulatory agents, so called adjuvants. Toll-like receptor (TLR) agonists, expressed, direct application of free TLR-agonists is limited by their relatively high toxicity receptors....

CD - Makromolekulární chemie

  • 2016 - 2018
    • •
  • 4 624 tis. Kč
    • •
  • 4 624 tis. Kč
    • •
  • GA ČR
Project

Personalized macromolecular vaccines agains cancer diseases (GA19-08176S)

and synthetic adjuvants (Toll-like receptor 7/8 agonists). These nanoparticle platforms avidity to the surface receptors of the immune cells or by increased toxicity, which......

Polymer science

  • 2019 - 2023
    • •
  • 4 613 tis. Kč
    • •
  • 4 589 tis. Kč
    • •
  • GA ČR
Project

Toll-like receptors in prostate carcinogenesis and therapy resistance (NV17-28518A)

. In the present translational project we will examine the role of toll-like receptors in regulation of cellular events associated with resistance. Toll-like receptors carcinogenesis has also been...

FD - Onkologie a hematologie

  • 2017 - 2021
    • •
  • 14 546 tis. Kč
    • •
  • 14 531 tis. Kč
    • •
  • MZ
Project

Advanced macromolecular vaccines for the treatment of infectious and neoplastic diseases (LTAUSA18173)

systems with synthetic adjuvants based on TLR7/8 agonists and peptide antigens...

Organic chemistry

  • 2019 - 2022
    • •
  • 5 880 tis. Kč
    • •
  • 5 880 tis. Kč
    • •
  • MŠMT
Project

Functional characteristics of circulating dendritic cells in patients with X-linked agammaglobulinemia (NS10489)

the crucial role of Toll-like receptors in the recognition of pathogens, we will study thefunction of all identified Toll like receptors on myeloid and plasmacytoid DC subsets......

EC - Imunologie

  • 2009 - 2011
    • •
  • 5 717 tis. Kč
    • •
  • 5 717 tis. Kč
    • •
  • MZ
Project

Molecular and cellular mechanisms in ethiopathogenesis of nasal polyposis (NS10054)

Signaling pathways and changes in expression of intracellular signaling molecules in nasal polyps. Expression of Toll-like receptors as potential markers for identifying etiological environmental factors in nasal polyps. Ch...

FF - ORL, oftalmologie, stomatologie

  • 2008 - 2011
    • •
  • 2 140 tis. Kč
    • •
  • 2 140 tis. Kč
    • •
  • MZ
Project

Antimicrobial peptides and Toll-like receptors in ontogeny and bacterial infections. (GA524/09/0365)

Antimicrobial peptides (AMPs) are endogeneous substances protecting organisms against infection. Basic knowledge of them and possibility of their induction is needed due to  increasing resistance of pathogenic bacteria against classical microbial ant...

EC - Imunologie

  • 2009 - 2014
    • •
  • 5 860 tis. Kč
    • •
  • 5 860 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of functional selectivity of atypical agonists at muscarinic receptors (GA305/09/0681)

agonists like xanomeline or AC-42, however, represent a new class of drugs that bind class agonists. We will apply functional assays to determine receptor activationEach of the five known subtypes of muscarinic ac...

ED - Fyziologie

  • 2009 - 2013
    • •
  • 6 959 tis. Kč
    • •
  • 6 959 tis. Kč
    • •
  • GA ČR
Project

Influence of metabotropic glutamate receptor agonists on cognitive deficit in animal model of schizophrenia like behavioral. (NR9178)

Propose testing of efficiency of drug affect metabotropic glutamate receptor on cognitive deficit in animal model of schizophrenia like behaviour will be useable to evaluation their applicability in clinical treatment. Influence of ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2007 - 2009
    • •
  • 6 339 tis. Kč
    • •
  • 6 339 tis. Kč
    • •
  • MZ
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