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184 (0,094s) •

Project

Role of calcium-dependent protein trans-splicing in the virulence of Gram-negative pathogens (GA19-15175S)

a new isopeptide bond, a process known as "Ca2+-dependent protein trans-splicing". The aim of the project is to determine the role of Ca2+-dependent trans-splicing on structural and functional characterization of ...

Microbiology

  • 2019 - 2022
    • •
  • 9 527 tis. Kč
    • •
  • 9 527 tis. Kč
    • •
  • GA ČR
Project

Functional analysis of methyltransferase involved in SL RNA modification in Trypanosoma brucei (GP204/08/P585)

The trypanosomatid SL RNA plays an essential role in trans-splicing, play a pivotal role in regulating the availability of trans-splicing "competent" SL RNA and, therefore, these enzymes might be major players in r...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 1 035 tis. Kč
    • •
  • 1 035 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanism of autocatalytic protein splicing of the RTX protein FrpC from Neisseria meningitidis (GAP207/11/0717)

residue (protein trans-splicing). The aim of this project is to determine the structure-function relationships underlying the mechanism of SPM-based protein splicingProtein splicing is a unique mechanism of autoca...

CE - Biochemie

  • 2011 - 2015
    • •
  • 14 100 tis. Kč
    • •
  • 14 100 tis. Kč
    • •
  • GA ČR
Project

The mechanism whereby the novel coactivator SNW regulates gene expression (GA204/02/1512)

of peptidyl-prolyl cis-trans isomerase, which suggests the interesting possibility thatSNW targets the splicing machinery and isomerase activities to the sites of ongoing in coupling transcription to splicing. Genetic anal...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 4 855 tis. Kč
    • •
  • 3 055 tis. Kč
    • •
  • GA ČR
Project

Regulation of alternative splicing via chromatin acetylation (GAP305/10/0424)

Alternative splicing (AS) is one of the key steps in gene expression that greatly increases coding potential of our genome. Splicing is regulated by numerous splicing regulators and target pre-mRNAs. In this project, we pro...

EB - Genetika a molekulární biologie

  • 2010 - 2013
    • •
  • 4 813 tis. Kč
    • •
  • 4 813 tis. Kč
    • •
  • GA ČR
Project

The role of alternative splicing in evolution of vertebrate body plan (LH12047)

extensive alternative splicing leading to a more complex genetic toolkit has not been splicing in Pax gene family. We will determine the degree of conservation of Pax splice forms within cephalochordates, compare alternati...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 2 885 tis. Kč
    • •
  • 2 885 tis. Kč
    • •
  • MŠMT
Project

Characterising the regulatory mechanisms at decoy 5’ splice sites (GF24-11219K)

In the last few years, it has been shown that cryptic splice sites can play an important role in regulating RNA splicing and thus gene expression. Many such cryptic we will focus on decoy 5’ splice sites (d-5’ss), which con...

Genetics and heredity (medical genetics to be 3)

  • 2024 - 2027
    • •
  • 8 364 tis. Kč
    • •
  • 8 329 tis. Kč
    • •
  • GA ČR
Project

Analysis of splicing factor mutations connected with the inherited retinitis pigmentosa (1K05009)

Pre-mRNA splicing is one of the key steps in the regulation of gene expression and mutations influencing pre-mRNA splicing were found in many genetic disorders in the formation of splicing complexes. Mutations of 61K and hP...

EB - Genetika a molekulární biologie

  • 2005 - 2006
    • •
  • 1 506 tis. Kč
    • •
  • 1 481 tis. Kč
    • •
  • MŠMT
Project

Molecular characterization of retinal and cerebellar defects caused by mutations in splicing factor Prpf8 (GA20-04099S)

Mutations in splicing factors are associated with diverse hereditary syndromes variants of splicing factor Prpf8, which genocopy human RP-linked mutations. Our pilot transcriptome analyses with iCLIP approach to identify RNA spl...

Biochemistry and molecular biology

  • 2020 - 2022
    • •
  • 10 124 tis. Kč
    • •
  • 10 124 tis. Kč
    • •
  • GA ČR
Project

BRCA1 alternative splicing variants and their prognostic and predictive role in breast cancer (NT12280)

The aim of the project is identification of BRCA1 splicing variants specificity their peripheral blood. BRCA1 mRNA splicing variants will be identified using cDNA splicing variants will be cloned into TA ? cloning vector an...

FD - Onkologie a hematologie

  • 2011 - 2014
    • •
  • 5 159 tis. Kč
    • •
  • 5 159 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 184