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9 654 (0,106s)

Project

Mechanisms of transcriptional pulsing (GA16-12611S)

Live cell imaging revealed that high transcriptional activity often alternates with periods of prolonged transcriptional silence. This phenomenon, referred to as transcriptional pulsing, is currently attracting con...

EB - Genetika a molekulární biologie

  • 2016 - 2017
  • 3 289 tis. Kč
  • 3 289 tis. Kč
  • GA ČR
Project

Study of siRNA populations of viral and transgenic transcripts associated with resistance in transgenic plum in interaction with Plum pox virus (LH15105)

for the analysis of siRNAs of viral and transgenic transcript and to assess the role of small RNA transcriptome in RNA silencing and stability of resistance in transgenic plum carrying transgenic transcript

GF - Choroby, škůdci, plevely a ochrana rostlin

  • 2015 - 2017
  • 1 740 tis. Kč
  • 1 740 tis. Kč
  • MŠMT
Project

Transkription activation system for studying the relationship between cytokinin metabolism and action in Arabidopsis and tobacco (IAA5004001)

Cytokinins (CKs) are known to act in combination with other phytohormones to regulate diverse developmental processes in plants. However, knowledge of molecualr mechanism of CK action is limited. We will use a novel transcription activat...

EB - Genetika a molekulární biologie

  • 2000 - 2002
  • 8 856 tis. Kč
  • 3 539 tis. Kč
  • AV ČR
Project

Role of Lineage Specific Transcription Factors GATA-1 and PU.1 in Hematopoietic Commitment and Leukemogenesis (GA301/06/1093)

Mutual antagonism between lineage specific transcription factors, erythroid GATA-1 and myeloid PU.1, is thought to transcriptionally regulate lineage commitment in chromatin. PU.1 plays a role in cancer: high levels of transcrip...

FD - Onkologie a hematologie

  • 2006 - 2008
  • 5 021 tis. Kč
  • 4 989 tis. Kč
  • GA ČR
Project

Novel Causative Genes Identification and Functional Study for selected Mendelian Disorders (LH14276)

. The project has several sub-aims: 1/ to describe the role of the candidate-gene transgenic in the patients with high myopia, 2/ the both transgenic models will be phenotyped to reveal in the context of vision, and 4/ additional

EB - Genetika a molekulární biologie

  • 2014 - 2016
  • 4 566 tis. Kč
  • 1 450 tis. Kč
  • MŠMT
Project

Transgenic rescue analysis of down-regulated genes involved in catecholamine biosynthesis in adrenal medulla of the spontaneously hypertensive rat (GAP301/12/0696)

integration of transcriptional, biochemical and linkage analyses in the adrenal tissue for simultaneous down-regulation of the transcription of several genes in the catecholaminergic pathway in the SHR. In the current project, we w...

EB - Genetika a molekulární biologie

  • 2012 - 2016
  • 9 557 tis. Kč
  • 9 557 tis. Kč
  • GA ČR
Project

Mendelian and non-mendelian interactions of the plant transgenes (IAA600040611)

We propose to study transgenic loci in tobacco plants. The research will be focused on inheritance and silencing properties of epiallelic variants of transgenes. As a basic model, we will use two epiallelic lines containing a tr...

EB - Genetika a molekulární biologie

  • 2006 - 2008
  • 1 415 tis. Kč
  • 1 415 tis. Kč
  • AV ČR
Project

Transcriptional and epigenetic control of pancreas development and function (GA22-11516S)

transcription factors involved in the development and survival of pancreatic ß cells will analyze one such transcription factor, NEUROD1. We will analyze the molecular altered regulation of NEUROD1 transcriptional networks...

Developmental biology

  • 2022 - 2024
  • 10 989 tis. Kč
  • 10 989 tis. Kč
  • GA ČR
Project

L1 retrotransposon-based transgenic chicken models (GA523/07/1171)

tocreate L1 transgenic chicken for in vivo studies of L1 integration and as a potential gene trap model. Our original transgenic technology using infection silencing and compared with the transgenic approach based on retro...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2007 - 2009
  • 4 247 tis. Kč
  • 4 247 tis. Kč
  • GA ČR
Project

Analysis of specificity and efficacy of RNAi in tobacco BY-2 cell line (LTC18047)

The main objective of the presented project is to downregulate the transcription of auxin metabolizing enzymes (auxin oxidase and auxin amino acid conjugating Gretchen-Hagen 3 family member). In transgenic culture evaluate the effic...

Plant sciences, botany

  • 2018 - 2020
  • 2 884 tis. Kč
  • 2 884 tis. Kč
  • MŠMT
  • 1 - 10 out of 9 654