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16 (0,063s) •

Project

Spermatogonial stem cells in the process of chicken spermatogenesis (ME 908)

To develop a joined project of experimental transgenesis in domestic fowl based on better understanding of gene expression during chicken spermatogenesis, identification of unique surface molecular markers of testicular spermatogonial cells ...

EB - Genetika a molekulární biologie

  • 2007 - 2011
    • •
  • 2 128 tis. Kč
    • •
  • 2 128 tis. Kč
    • •
  • MŠMT
Project

Avian Sarcoma and Leukosis Virus-based Vectors and Their Potential for Transgenesis in Chicken (GAP502/11/2207)

Retroviruses are important tools as gene delivery vectors for transgenesis and even gene therapy. The crucial requirements for both applications are the long-term as vectors for transgenesis and even for gene therapy with minimum ge...

EB - Genetika a molekulární biologie

  • 2011 - 2015
    • •
  • 5 864 tis. Kč
    • •
  • 5 864 tis. Kč
    • •
  • GA ČR
Project

Transgenic models of transposon insertional mutagenesis in domestic chicken (GA19-23407S)

been hampered up to now due to the low efficiency of transgenesis in birds. Our original approach now opens new avenues to transgenesis in chicken and we suggest......

GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming

  • 2019 - 2023
    • •
  • 8 891 tis. Kč
    • •
  • 8 396 tis. Kč
    • •
  • GA ČR
Project

Cardiovascular risk factors cluster analyzed by transgenesis of the peroxisome proliferatoractivated receptor gamma (GA301/01/0278)

The thiazolidinediones (TZD) belongs to a class of insulin-sensitizing, antidiabetic drugs which exert their effects through interactions with peroxisome proliferator-activated receptor gamma (PPARgamma). Although PPARgamma is one of the best charact...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 5 017 tis. Kč
    • •
  • 3 564 tis. Kč
    • •
  • GA ČR
Project

L1 retrotransposon-based transgenic chicken models (GA523/07/1171)

L1 retrotransposons are major long interspersed nucleotide elements (LINEs) within the human genome. As autonomous retrotransposons, L1s were recently used for transgenesis in mouse and for transduction of RNA interference-inducing shRNAs. W...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2007 - 2009
    • •
  • 4 247 tis. Kč
    • •
  • 4 247 tis. Kč
    • •
  • GA ČR
Project

Development of new transgenic technologies for biomedical research and pharmaceutical industry (TA02010013)

The aims of the project are (1) to develop and optimize technologies for transgenesis of the laboratory rat with transposon system Sleeping Beauty and highly effective SB100X transposase and develop RMCE (recombinase mediated cassette exchan...

EB - Genetika a molekulární biologie

  • 2012 - 2016
    • •
  • 15 865 tis. Kč
    • •
  • 9 930 tis. Kč
    • •
  • TA ČR
Project

Pathogenesis of cardiovascular risk factors cluster analyzed by transgenesis with Srebp1c transcription factor (NB6468)

Sterol regulatory element binding protein 1c (Srebplc) could be a central mediator of the genomic actions of insulin on carbohydrate and lipid metabolism and might thus contribute to the pathogenesis of type 2 diabetes or obesity. To test this hypoth...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 5 033 tis. Kč
    • •
  • 3 454 tis. Kč
    • •
  • MZ
Project

Identification of interactors of the meiotic histone methyltransferase Hybrid sterility 1 (PR-domain 9) (GAP305/10/1931)

immunoprecipitation, yeast two hybrid system, targeted crosses, transgenesis, and other...

EB - Genetika a molekulární biologie

  • 2010 - 2013
    • •
  • 6 107 tis. Kč
    • •
  • 6 107 tis. Kč
    • •
  • GA ČR
Project

Steroid signaling in insects classical and new genetic approaches (IAA5007305)

Steroid signaling underlies important events in insect life: molting, metamorphosis and reproduction. Insect make their steroid hormones ecdysones from cholesterol in a process whose regulation is poorly understood. We cloned a gene ecdysoneless, res...

EB - Genetika a molekulární biologie

  • 2003 - 2007
    • •
  • 3 214 tis. Kč
    • •
  • 2 728 tis. Kč
    • •
  • AV ČR
Project

Integrated microRNA, mRNA expression profiling, linkage and correlation analyses for identification of genes underlying complex traits (GAP301/10/0290)

level. Functional relevance of selected miRNA will be established using transgenesis...

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 6 393 tis. Kč
    • •
  • 6 393 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 16