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755 (0,119s) •

Project

The role of endothelin in the pathogenesis of hypertension in transgenic (mRen2) 27 rats (NA6523)

In transgenic rats TGR (mRen2)27 hyperproducing renin, the possible role of endothelin (ET) in the mechanism of their hypertension will be studied by the use of a chronic administration of ET receptor antagonist, bosentan.......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2001 - 2003
    • •
  • 726 tis. Kč
    • •
  • 726 tis. Kč
    • •
  • MZ
Project

Transgenic rats for analysis of expresion and function of Thy-1 glycoprotein in rat mast cells (GA301/96/0897)

will produce transgenic rats carrying genomic clones of mouse Thy-1.2 and will analyze theexpression of the transgenic product in mast cells and other cell types. Thy-1.1/Thy-1.2 paid to find optimal conditions for product...

EB - Genetika a molekulární biologie

  • 1996 - 1998
    • •
  • 2 973 tis. Kč
    • •
  • 2 397 tis. Kč
    • •
  • GA ČR
Project

Development of new transgenic technologies for biomedical research and pharmaceutical industry (TA02010013)

The aims of the project are (1) to develop and optimize technologies for transgenesis of the laboratory rat with transposon system Sleeping Beauty and highly effective SB100X transposase and develop RMCE (recombinase mediated cassette exchan...

EB - Genetika a molekulární biologie

  • 2012 - 2016
    • •
  • 15 865 tis. Kč
    • •
  • 9 930 tis. Kč
    • •
  • TA ČR
Project

Impaire ability of kidney to excrete sodium under conditions of normal blood pressure as the main cause of development of hypertension. (NE6358)

The role of the renin-angiotensin system and nitric oxide is to be investigated in transgenic rats with murine renin gene insertion.......

FG - Pediatrie

  • 2000 - 2002
    • •
  • 1 615 tis. Kč
    • •
  • 1 568 tis. Kč
    • •
  • MZ
Project

A new insight on the role of the renin-angiotensin system in blood pressure regulation and development of hypertension-a study in transgenic rats with inducible hypertension (NR7956)

The role of the renin-angiotensin system in the control of blood pressure and development of hypertension will be studied in transgenic rats with inducible hypertension.......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2004 - 2006
    • •
  • 3 213 tis. Kč
    • •
  • 3 188 tis. Kč
    • •
  • MZ
Project

The pathogenesis of hypertensive end-organ damage in Ren-2 transgenic rats-the role of endothelin receptors (ETA and ETB) (NR7826)

The role of endothelin receptors ETA and ETB and its effect on the onset and development of hypertension-related organ damage in Ren-2 transgenic rats will be studied.......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2004 - 2006
    • •
  • 2 858 tis. Kč
    • •
  • 2 828 tis. Kč
    • •
  • MZ
Project

The role of the interaction of the AT1 and AT2 angiotensin II receptors in the ontogenesis of hypertension a study in "Ren-2" transgenic rats (NR8550)

The role of the interaction of the AT1 and AT2 angiotensin II receptors in the ontogenesis of hypertension will be studied in the model of "Ren-2" transgenic rats.......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2005 - 2007
    • •
  • 4 838 tis. Kč
    • •
  • 4 728 tis. Kč
    • •
  • MZ
Project

Contribution of the RAAS to the pathophysiology of salt-sensitive hypertension a study in renin transgenic rats with inducible hypertension (GP305/08/P053)

ofrenin transgenic rats with inducible hypertension, which express the mouse Ren-2 regulating the activity of the RAAS. This transgenic rat model allows assessment......

ED - Fyziologie

  • 2008 - 2010
    • •
  • 1 485 tis. Kč
    • •
  • 1 485 tis. Kč
    • •
  • GA ČR
Project

Simulation of alloantigen-independent risk factors for chronic allograft nephropathy in an experimental model and its potential treatment (ND6641)

The aim of the project is to evaluate the effect of ischemia/reperfusion injury in hypertensive transgenic rat. The second aim of the study is to evaluate the effect of renin-angiotensin system inhibition in hypertension accelerated...

FJ - Chirurgie včetně transplantologie

  • 2001 - 2003
    • •
  • 1 014 tis. Kč
    • •
  • 951 tis. Kč
    • •
  • MZ
Project

Transgenic rescue analysis of down-regulated genes involved in catecholamine biosynthesis in adrenal medulla of the spontaneously hypertensive rat (GAP301/12/0696)

rat (SHR) and Brown Norway (BN-Lx) progenitors and obtained evidence pathway in the SHR. In the current project, we will use transgenic rescue experiments the mechanisms responsible for cardiovascular effects associated with tr...

EB - Genetika a molekulární biologie

  • 2012 - 2016
    • •
  • 9 557 tis. Kč
    • •
  • 9 557 tis. Kč
    • •
  • GA ČR
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