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6 489 (0,2s) •

Project

Transition-state mimicking inhibitors of human betaine homocysteine S-methyltransferase (IAA4055302)

inhibitors of human betaine: homocysteine S-methyltransferase (BHMT). These new inhibitors will mimic the structure of the hypothetical transition-state of substrates the transition-state are pla...

CC - Organická chemie

  • 2003 - 2005
    • •
  • 2 825 tis. Kč
    • •
  • 1 629 tis. Kč
    • •
  • AV ČR
Project

Thiazoline inhibitors of ?-N-acetylhexosaminidase based on new, non-natural substrates. (GAP207/11/0629)

New, potent and more selective ?-HexNAc-thiazoline inhibitors of ?-N-acetylhexosaminidase mimicking their oxazoline transition state, with a therapeutic potential, will be designed and prepared. New inhibitor struc...

CE - Biochemie

  • 2011 - 2014
    • •
  • 5 907 tis. Kč
    • •
  • 5 907 tis. Kč
    • •
  • GA ČR
Project

New generations of cyclin-dependent kinase inhibitors with significant anticancer properties (GA301/05/0418)

)-6-benzylamino-9-methylpurine) as one of the first specific inhibitors of cyclin phases ofcell cycle such as G1/S and G2/M transition. The design and inhibitory activity at the G1/S and G2/M transitions of the cell divisio...

FD - Onkologie a hematologie

  • 2005 - 2007
    • •
  • 11 979 tis. Kč
    • •
  • 4 995 tis. Kč
    • •
  • GA ČR
Project

Small-molecule inhibitors of mitochondrial permeability transition for treatment of myocardial ischemia-reperfusion injury (NU22J-02-00006)

permeability transition pore. This process can be suppressed by targeting mitochondrial inhibitor was shown to protect heart muscle after myocardial infarction. However, currently known inhibitors failed to deliver expecte...

Cardiac and Cardiovascular systems

  • 2022 - 2025
    • •
  • 6 998 tis. Kč
    • •
  • 6 998 tis. Kč
    • •
  • MZ
Project

Novel potent and selective pseudopeptide inhibitors of methionine aminopeptidases 1 and 2 (GA203/06/1405)

inhibitors of bacterial methionine aminopeptidases 1 and 2 and human methionine aminopeptidase 2. These new inhibitors will mimic the structure of the hypothetical transition-stateof substrate upon binding to enzyme active...

CC - Organická chemie

  • 2006 - 2008
    • •
  • 1 678 tis. Kč
    • •
  • 1 678 tis. Kč
    • •
  • GA ČR
Project

Chemical synthesis of human pathogens proteases inhibitors (GP203/02/P095)

We propose to design and synthesize compounds with hydroxyethyl secondary amine isostere of peptide bond. This transition state isostere appeared to be a good mimic of the natural aspartic protease substrate cleavage sites. Compound...

CC - Organická chemie

  • 2002 - 2004
    • •
  • 750 tis. Kč
    • •
  • 625 tis. Kč
    • •
  • GA ČR
Project

Development of a molecular toolkit for control and investigation of the bacterial stringent response (GA15-11711S)

inhibitors is a promising strategy for the design of novel antibacterials...

CC - Organická chemie

  • 2015 - 2017
    • •
  • 4 390 tis. Kč
    • •
  • 4 390 tis. Kč
    • •
  • GA ČR
Project

Structure, stability and spectral properties of transition metals complexes with cytokinines and inhibitors of cyclin-dependent kinases A Molecular modelling (IAA401370901)

Cytokinins and cyclin-dependent kinases inhibitors are physiologically active compounds that influence processes of the cell cycle regulation. This effect can be strongly increased by coordination of their molecules to ions of suitable t...

CA - Anorganická chemie

  • 2009 - 2011
    • •
  • 1 466 tis. Kč
    • •
  • 1 466 tis. Kč
    • •
  • AV ČR
Project

Properties and dynamics of electronic states of transition metal complexes (OC09043)

To unravel new means of control of properties and dynamics of charge transfer excited states of transition metal complexes and of redox states of oligonuclear complexes containing non-innocent ligands. To unravel and unders...

CF - Fyzikální chemie a teoretická chemie

  • 2009 - 2010
    • •
  • 1 000 tis. Kč
    • •
  • 1 000 tis. Kč
    • •
  • MŠMT
Project

Structural and functional characterization of cathepsins and their inhibitors (IAA4055006)

level can lead to a serious pathological state. The aim of the project of their activity, specificity, and interaction with inhibitors. Inhibitor topic is focused on characterization of two categories of inhibitors

CE - Biochemie

  • 2000 - 2002
    • •
  • 2 212 tis. Kč
    • •
  • 967 tis. Kč
    • •
  • AV ČR
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