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6 424 (0,216s) •

Project

In-depth analysis of the function and regulatory potential of individual subunits of human translation initiation factor 3 and their subcomplexes. (GA17-06238S)

Translation is a fundamental process critically contributing to regulation of gene expression. Because most regulation occurs during the initiation phase, its expression of eIF3 subunits and other...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 7 476 tis. Kč
    • •
  • 7 476 tis. Kč
    • •
  • GA ČR
Project

AML1 gene and HOX genes in pathogenesis of childhood acute leukaemias (NR9526)

by quantitative determination of expression of individual HOX genes in patients' samples in comparison with gene expression in maturational normal myeloid cells. We will determine and further study the mechanisms ...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 7 534 tis. Kč
    • •
  • 7 531 tis. Kč
    • •
  • MZ
Project

Molecular basis of the gene-specific translational control mechanism of yeast GCN4 and its mammalian functional homologue ATF4. (GAP305/11/0172)

Exploration of translational control mechanisms provides important insight into regulation of cellular processes such as proliferation, differentiation and apoptosis. We are interested in one such a mechanism called reinitiation (RE...

EB - Genetika a molekulární biologie

  • 2011 - 2016
    • •
  • 7 668 tis. Kč
    • •
  • 7 668 tis. Kč
    • •
  • GA ČR
Project

Identification of proteins involved in the posttranscriptional regulation of expression of tobacco (Nicotiana tabacum) male gametophyte-specific genes (IAA5038801)

Male gemetophyte presents a natural system for the study of the gene expression. The Ntp303 gene, transcribed and stored in immature bovacco pollen and translated of the mechanism of the regulation of ...

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 4 671 tis. Kč
    • •
  • 1 702 tis. Kč
    • •
  • AV ČR
Project

Role of cytoskeleton in dynamics of ntp303 mRNA distribution, storage and activation in the process of tobacco pollen maturation and tube growth (IAA5038207)

Tobacco pollen specific ntp303 gene represents a natural model of translational regulation of gene expression. Pollen tube growth is dependent on intensive synthesis of the pollen tube wall glycoprotein, p...

EB - Genetika a molekulární biologie

  • 2002 - 2005
    • •
  • 10 105 tis. Kč
    • •
  • 3 254 tis. Kč
    • •
  • AV ČR
Project

Redox signalling to chromatin during stress responses in plants (GA22-17092S)

on gene expression, the molecular mechanisms regulating the acetylation activity central mechanisms for regulation of gene expression under stress conditions and pave reprogramming that is partia...

Plant sciences, botany

  • 2022 - 2024
    • •
  • 4 911 tis. Kč
    • •
  • 4 911 tis. Kč
    • •
  • GA ČR
Project

Importance of nucleoprotein complexes for the regulation of the male gametophyte development (OC08011)

in the process of regulation of pollen specific gene expression. Within a scope of current for the regulation of transcription and translation in developing male gametophyte. The main gametophyte represen...

ED - Fyziologie

  • 2008 - 2011
    • •
  • 2 430 tis. Kč
    • •
  • 1 625 tis. Kč
    • •
  • MŠMT
Project

Targeting the IRES-driven translation mechanism as a new strategy to prevent cancer development (GCP305/10/J026)

translational regulation. Two kinds of mechanisms, cap-dependent scanning and internal, cellular transformation and regulation of apoptosis. IRES-driven translation may help them to escape many control mechanisms ...

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 4 336 tis. Kč
    • •
  • 4 336 tis. Kč
    • •
  • GA ČR
Project

Depicting a functional model of NTP303 mRNA translational repression during tobacco pollen maturation (GPP501/11/P321)

Posttranscriptional control of gene expression plays a vital role during tobacco pollen maturation and pollen tube growth. A pollen-specific gene NTP303 cell wall. The expression of NTP303 gene is detected...

ED - Fyziologie

  • 2011 - 2013
    • •
  • 3 034 tis. Kč
    • •
  • 3 034 tis. Kč
    • •
  • GA ČR
Project

Molecular basis of Staufen-mediated 3'UTR function (GA18-08153S)

’UTR functions in posttranscriptional regulation of gene expression and thus transport, translational control and mRNA decay. Despite the importance of 3’UTRs for spatial and temporal control of gene ...

Biochemistry and molecular biology

  • 2018 - 2021
    • •
  • 11 281 tis. Kč
    • •
  • 11 081 tis. Kč
    • •
  • GA ČR
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