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933 (0,324s) •

Project

Molecular-cytogenetic analysis of marked plasma cells and prognostic significance of clonal chromosomal aberrations in multiple myeloma (NR8183)

Detection of selected clonal chromosomal aberrations in immunofluorescence-marked plasma cells in patients with multiple myeloma using molecular cytogenetic methods. Evaluation of the impact of selected chromosomal abnormalities on the prognosis of p...

FD - Onkologie a hematologie

  • 2004 - 2007
    • •
  • 3 329 tis. Kč
    • •
  • 3 091 tis. Kč
    • •
  • MZ
Project

Cloning and analysis of genes involved in spermatogenic in carriers of chromosomal translocations and selfish t-haplotypes (GA301/99/0354)

testis-specific transcripts of mice carrying t-haplotypes and of sterile males carrying the T43 chromosomal translocation. The transcripts unigue for t-carrying male mouse models. The t- haptolypes are trans-actin...

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 3 285 tis. Kč
    • •
  • 2 785 tis. Kč
    • •
  • GA ČR
Project

Chromosomal rearrangements with breakpoints in T cell receptor genes (GAP502/12/1966)

T cell receptor genes (TR) are rearranged during maturation of T cells by site of different TR genes takes place, resulting in reciprocal translocation or inversion of chromosomes. Rearrangements of TR genes with oncogenes ...

EB - Genetika a molekulární biologie

  • 2012 - 2014
    • •
  • 4 855 tis. Kč
    • •
  • 4 855 tis. Kč
    • •
  • GA ČR
Project

In utero origin in childhood acute lymphblastic leukemia. (NE6292)

for identification of leukaemogenic translocations t (4;11) and t (12;21) in physiological cord...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 2 121 tis. Kč
    • •
  • 2 121 tis. Kč
    • •
  • MZ
Project

WT1 gene in childhood leukaemias and its importance in minimal residual disease follow-up (GA312/98/P304)

of non-random chromosomal translocations t(9;22), t(4;11) and t(12;21) using RT-PCR and/or detection of clonospecific immunoglobulin and T-cell receptor gene rearrangements......

FD - Onkologie a hematologie

  • 1998 - 2001
    • •
  • 714 tis. Kč
    • •
  • 714 tis. Kč
    • •
  • GA ČR
Project

Salmonella effector network inhibiting T cell immunity (GM24-11259M)

to establish a long-lasting niche in its host by inhibiting crucial T cell response to translocate effectors inhibiting migration of dendritic cells, inducing anti-inflammatory in subversion of the T cell immunity. This le...

Microbiology

  • 2024 - 2028
    • •
  • 24 137 tis. Kč
    • •
  • 24 137 tis. Kč
    • •
  • GA ČR
Project

Characterization of the molecular machinery regulating the recruitment of signaling molecules to lipid rafts (GA310/09/2084)

Lipid raft-based, plasma membrane compartmentalization processes are essential for spatial and temporal regulation of signaling events in T cells. T cell signaling leads of kinase active Lck to lipid rafts (LR). While this event is ...

EC - Imunologie

  • 2009 - 2014
    • •
  • 6 750 tis. Kč
    • •
  • 6 750 tis. Kč
    • •
  • GA ČR
Project

Genetically downregulated expression of the immune checkpoint inhibitor LAIR-1 in tumor-specific T cells as a novel strategy for breaking the resistance of solid tumors to adoptive T cell (NU23-08-00071)

expressed on T cells. LAIR-1 binds to collagen, the major component of the tumor microenvironment, and this binding prevents T cells from translocation to and inside a tumor patients with solid tumors still do not benefit ...

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2023 - 2026
    • •
  • 11 244 tis. Kč
    • •
  • 11 244 tis. Kč
    • •
  • MZ
Project

Study of meiotic disturbances in men - carriers of congenital balanced translocations and their effect on the outcome of assisted reproduction (NS9842)

Presence of a congenital balanced translocation in the karyotype is a common of an affected child depends on the type of translocation. Statistical evaluation segregation of translocated chromosomes and their normal homolog...

EB - Genetika a molekulární biologie

  • 2008 - 2011
    • •
  • 4 951 tis. Kč
    • •
  • 4 297 tis. Kč
    • •
  • MZ
Project

The study of pathogenesis and clinical importance of MLL gene rearrangements in acute leukemias (AL) (NR7849)

Molecular cytogenetics, molecular genetics and translocation biochip in determination chromosomal translocations involving the MLL gene. Determination of novel MLL-fusion partners in patients with new, undescribed translocations...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 3 863 tis. Kč
    • •
  • 3 333 tis. Kč
    • •
  • MZ
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