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3 887 (0,133s) •

Project

Optimized dendritic cells loaded with universal tumor antigens as a potent individualized cancer vaccine (NS9871)

This study aims to prepare a clinical grade cancer vaccine based on optimized dendritic cells loaded with tumor associated antigens tailored for each individual patient.......

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 8 171 tis. Kč
    • •
  • 8 171 tis. Kč
    • •
  • MZ
Project

Molecules Associated with Carcinoembryonic Antigen in Normal and Tumor Tissues (GA301/93/0323)

9H - 9

  • 1993 - 1995
    • •
  • 612 tis. Kč
    • •
  • 1 224 tis. Kč
    • •
  • GA ČR
Project

Immunotherapy Using Different Tumor Antigens in The Treatment of Multiple Myeloma (NR8945)

using dendritic cells loaded with different myeloma antigens. Irradiated myeloma cells, myeloma mRNA or peptides derived from tumor associated proteins will be used as tumor antigens. This approach will l...

FD - Onkologie a hematologie

  • 2006 - 2009
    • •
  • 6 929 tis. Kč
    • •
  • 6 587 tis. Kč
    • •
  • MZ
Project

Knowledge deepening on immunology of chronic myeloid leukemia necessary precondition of future terapeutic vaccine (NT12363)

of 15-20 selected antigens, determination of the cellular and humoral immunity to these antigens, and correlation of the findings with the clinical picture. An attempt to determine the optimal time for administering the anti-tu...

FD - Onkologie a hematologie

  • 2011 - 2015
    • •
  • 10 493 tis. Kč
    • •
  • 9 457 tis. Kč
    • •
  • MZ
Project

Evaluation of dentritic cells administration in multiple myeloma. (NC6152)

their prognosis by using administration of dendritic cells primed with specific antigen. Idiotypic proteinor peptides from myeloma cells lysate will be used as tumor associated antigens.......

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 1 054 tis. Kč
    • •
  • 1 054 tis. Kč
    • •
  • MZ
Project

Glutamate Carboxypeptidase II and its role in cancer development (GAP304/12/0847)

-associated neovasculature of most solid tumors and represents thus a very promising antigen (PSMA) or folate hydrolase I (FOLH1) is expressed in the brain, prostate its splicevariants in prostate carcinoma and brain tu...

EB - Genetika a molekulární biologie

  • 2012 - 2014
    • •
  • 15 185 tis. Kč
    • •
  • 15 185 tis. Kč
    • •
  • GA ČR
Project

Combined Immunotherapy of Tumours Induced by Human Papillomavirus (NR8004)

The aim of the project is to develop an immunotherapeutic procedure against papilloma virus-associated tumours employing prime/boost strategy. The approach combines heterologous vaccines. They include DNA vaccines, recombinant vaccinia virus...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 13 021 tis. Kč
    • •
  • 10 895 tis. Kč
    • •
  • MZ
Project

Development of experimental vaccine against WT 1 for immunotherapy of tumors (NS10660)

it was evaluated as a promising target antigen for immunotherapy of tumors. WT1 geneWT1 gene is highly expressed in myeloid leukemia and in some solid tumors expression, which could increase sensitivity of tumor c...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 10 317 tis. Kč
    • •
  • 10 317 tis. Kč
    • •
  • MZ
Project

Imunization against Tumors Characterized by Different Escape Mechanisms (NC7552)

Imunization against mouse tumor cells with reduced expression of MHC class I molecules and /or tumor antigen (oncoprotein E7 of human papillomavirus type 16). Utilization of DNA vaccines, cellular vaccines and recombinant a...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 12 151 tis. Kč
    • •
  • 11 594 tis. Kč
    • •
  • MZ
Project

Development of anti-tumor DNA vaccines based on fusion of immunogen with E. coli beta-glucuronidase and enhancement of their effect by stimulation of non-specific immunity (NR9246)

Enhancement of efficacy of therapeutic anti-tumor vaccines based on fusion of a tumor antigen with E. coli beta-glucuronidase. Increase of production of immunogens of a tumor antigen.. of immunization effe...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 8 294 tis. Kč
    • •
  • 8 104 tis. Kč
    • •
  • MZ
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