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Removing tumour cells defences Defining and inhibiting the survival pathways exploited by tumour cells that suppress Fas-mediated apoptosis (GA301/00/0563)
transformation will be emloyed to explore hoe tumor-promoting viruses suppress the apototic induces apoptosis in sensitive cells. Fas-mediated apoptosis is often suppressed in tumors that originate from Fas-sensit...
FD - Onkologie a hematologie
- 2000 - 2002 •
- 1 802 tis. Kč •
- 1 552 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2000 - 1. 1. 2002
Uznané náklady
Podpora ze státního rozpočtu (86%)
Poskytovatel: Grantová agentura České republiky
Polymer prodrugs acting as endogenous vaccines for synergic tumor therapy using immunomodulation and immune checkpoint blockade (GA17-08084S)
The principal objective of the project is to study combined tumor treatment vaccines, inhibition of suppressive activity of myeloid-derived suppressor cells (MDSC) in tumor microenvironment, and immune checkpoint blockade u...
FD - Onkologie a hematologie
- 2017 - 2021 •
- 8 334 tis. Kč •
- 8 010 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2017 - 31. 12. 2021
Uznané náklady
Podpora ze státního rozpočtu (96%)
Poskytovatel: Grantová agentura České republiky
The idtroduction of comparative genomic hybridization in chidhood ALL to detection and study of clinical importance of genetic changes. (IZ4026)
. aberrations in childhood ALL.The differentially labeled tumor and control DNA are cohybridized to normal chromosomes under suppress. conditions and detected using defferent fluorochr.The ratios of fliorescence intensities generate...
FG - Pediatrie
- 1997 - 1999 •
- 1 904 tis. Kč •
- 1 904 tis. Kč •
- MZ
Řešení projektu: 1. 1. 1997 - 1. 1. 1999
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Preparation of multifunctional thermal responsive hydrogel for tumor-vascular normalization combined with radiation and immunotherapy (TF06000093)
The project is focused to preparation of immunoprotective nanopharmaceuticals suppressing the undesirable consequences of radio- and chemotherapy of tumors) and trehalose (TLR2). Verification of the functionality of presented multim...
Organic chemistry
- 2019 - 2021 •
- 17 771 tis. Kč •
- 12 440 tis. Kč •
- TA ČR
Řešení projektu: 1. 1. 2019 - 31. 12. 2021
Uznané náklady
Podpora ze státního rozpočtu (70%)
Poskytovatel: Technologická agentura ČR
Telomere homeostasis from colorectal adenoma to metastatic cancer. (GA21-27902S)
proliferation, survival and differentiation. The hTERT subunit adopts tumor suppressing cancer. In advanced tumors the telomerase activation within epithelial-to-mesenchymal to migrate from the primary site of the tumo...
Oncology
- 2021 - 2024 •
- 12 958 tis. Kč •
- 12 958 tis. Kč •
- GA ČR
Řešení projektu: 1. 7. 2021 - 30. 6. 2024
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Comparative genomic hybridization (CGH) - new method of the detection of chromosomal aberrations in chronic B-cell leukemias (GA312/97/0125)
for the procedure. Differentially labeled tumor and genomic control DNA are cohybridized to normalmetaphase chromosome under suppression conditions and detected using different fluorochromes. The ratio of the fluorescence intensiti...
FD - Onkologie a hematologie
- 1997 - 1999 •
- 4 101 tis. Kč •
- 4 101 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 1997 - 1. 1. 1999
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Empowering the p53 to trigger cell death in tumors (GA25-18368S)
Previous efforts to utilize targeted activation of the p53 tumor suppressor in oncotherapy were crippled by the prevailing response to p53 activation, which resistant to p53 monotherapies, and arrests tumor growth in vivo. By genomi...
Biochemistry and molecular biology
- 2025 - 2027 •
- 8 566 tis. Kč •
- 8 167 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2025 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (95%)
Poskytovatel: Grantová agentura České republiky
Inhibition of JAK/STAT3 signalling pathway in cancer therapy (GA18-14259S)
progression and to suppress adverse effects of senescent cells on tissue microenvironment able to inhibit a tumor growth and development of cellular senescence and to evaluate the efficacy of current and novel STAT3 inhibitors to i...
Medicinal chemistry
- 2018 - 2022 •
- 11 770 tis. Kč •
- 11 355 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2018 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (96%)
Poskytovatel: Grantová agentura České republiky
Molecular mechanisms of the tumor suppressor function of the HIC1 gene (GAP305/12/2347)
The research objective of the project is to define the tumor suppressive function of Hic1, transcription repressor that is frequently inactivated in many types of cancer. The experimental work is based on the manipulation of the Hic...
EB - Genetika a molekulární biologie
- 2012 - 2015 •
- 9 953 tis. Kč •
- 9 953 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2012 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
REGULATION OF CELL MOTILITY AND PROLIFERATION BY ERK PATHWAY AND ERK PATHWAY SCAFFOLDS. (IAA500200716)
The microenvironment surrounding primary tumor cells can temporarily change tumor cell gene expression, resulting in growth suppression and increased motility. Once cells reach a favorable milieu, they reactivate the prolif...
EB - Genetika a molekulární biologie
- 2007 - 2010 •
- 3 345 tis. Kč •
- 3 345 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 2007 - 31. 12. 2010
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Akademie věd České republiky
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