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7 500 (0,097s) •

Project

Immunotherapy Using Different Tumor Antigens in The Treatment of Multiple Myeloma (NR8945)

using dendritic cells loaded with different myeloma antigens. Irradiated myeloma cells, myeloma mRNA or peptides derived from tumor associated proteins will be used as tumor antigens. This approach will lead to th...

FD - Onkologie a hematologie

  • 2006 - 2009
    • •
  • 6 929 tis. Kč
    • •
  • 6 587 tis. Kč
    • •
  • MZ
Project

Development of experimental vaccine against WT 1 for immunotherapy of tumors (NS10660)

it was evaluated as a promising target antigen for immunotherapy of tumors. WT1 gene to effect of antigen specific adaptive cellular immunity elicited by immunizationWT1 gene is highly expressed in myeloid leukemi...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 10 317 tis. Kč
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  • 10 317 tis. Kč
    • •
  • MZ
Project

Non-replicative vectors for induction of specific cellular immune responses (GA310/01/0934)

A challenge in vaccine development is the design of efficient means for induction of cellular immune responses. While exogenous antigens are mainly presented on MHC class II molecules, endogenous viral, parasite and tumor antige...

EC - Imunologie

  • 2001 - 2003
    • •
  • 4 552 tis. Kč
    • •
  • 3 632 tis. Kč
    • •
  • GA ČR
Project

Development of anti-tumor DNA vaccines based on fusion of immunogen with E. coli beta-glucuronidase and enhancement of their effect by stimulation of non-specific immunity (NR9246)

Enhancement of efficacy of therapeutic anti-tumor vaccines based on fusion of a tumor antigen with E. coli beta-glucuronidase. Increase of production of immunogens of a tumor antigen.. of immunization effe...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 8 294 tis. Kč
    • •
  • 8 104 tis. Kč
    • •
  • MZ
Project

Glutamate Carboxypeptidase II and its role in cancer development (GAP304/12/0847)

Glutamate carboxypeptidase II (GCPII), also known as prostate specific membrane antigen (PSMA) or folate hydrolase I (FOLH1) is expressed in the brain, prostate-associated neovasculature of most solid tumors and represents ...

EB - Genetika a molekulární biologie

  • 2012 - 2014
    • •
  • 15 185 tis. Kč
    • •
  • 15 185 tis. Kč
    • •
  • GA ČR
Project

Optimized dendritic cells loaded with universal tumor antigens as a potent individualized cancer vaccine (NS9871)

This study aims to prepare a clinical grade cancer vaccine based on optimized dendritic cells loaded with tumor associated antigens tailored for each individual patient.......

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 8 171 tis. Kč
    • •
  • 8 171 tis. Kč
    • •
  • MZ
Project

Novel biologics for cancer imaging (GAP301/12/1513)

The proposal is aimed at the development of biologics that will be used for solid tumor imaging, with the particular focus on prostatic carcinoma (PCa). We a ribosome display screen to select ligands specifically binding prostate-

EB - Genetika a molekulární biologie

  • 2012 - 2016
    • •
  • 11 017 tis. Kč
    • •
  • 11 017 tis. Kč
    • •
  • GA ČR
Project

Determination of tumor mRNA in patients with colorectal carcinoma as a screening and prognostic method using reverse-transcriptase polymerase chain reaction RT-PCR and comparison with traditional (NR7894)

with determination of usual tumor markers - carcinoembrional antigen CEA, antigen Ca 19-9To determine a level of tumor mRNA in a tumor focus and blood of patients using. To consider a malignity degree and...

FJ - Chirurgie včetně transplantologie

  • 2004 - 2006
    • •
  • 1 743 tis. Kč
    • •
  • 1 729 tis. Kč
    • •
  • MZ
Project

Evaluation of dentritic cells administration in multiple myeloma. (NC6152)

their prognosis by using administration of dendritic cells primed with specific antigen. Idiotypic proteinor peptides from myeloma cells lysate will be used as tumor associated antigens.......

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 1 054 tis. Kč
    • •
  • 1 054 tis. Kč
    • •
  • MZ
Project

Personalized macromolecular vaccines agains cancer diseases (GA19-08176S)

Active immunization by means of tumor-specific antigens (neoantigens) represents a very promising way of individualized immunotherapy of cancer diseases all together result in insufficient production of T-cells capable of <...

Polymer science

  • 2019 - 2023
    • •
  • 4 613 tis. Kč
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  • 4 589 tis. Kč
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  • GA ČR
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