All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”
EN
ČeštinaEnglish

Filters

7 778 (0,103s) •

Project

The role of selected chemokine receptors and interferone-beta in the pathogenesis of rheumatoid arthritis (NI6459)

Identification of the role for CXCR3 and CCR5 and their ligands in the synovial tissue of patients with early rheumatoid arthritis. Exploration of the role of interferon beta in the synovial inflammation and assessment of its suppresive effe...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2001 - 2003
    • •
  • 3 146 tis. Kč
    • •
  • 3 120 tis. Kč
    • •
  • MZ
Project

Sensing of HIV-1 by plasmacytoid dendritic cells dichotomy of immunoreceptor signaling (GA14-32547S)

The role of plasmacytoid dendritic cells (pDCs), the major source of type I interferon (IFN-I) in human organism, in pathogenesis of HIV-1 infection is not clear. In contrast to HIV-1 infected lymphocytes, HIV-1 vi...

EE - Mikrobiologie, virologie

  • 2014 - 2018
    • •
  • 6 397 tis. Kč
    • •
  • 6 397 tis. Kč
    • •
  • GA ČR
Project

Autoantibodies as critical determinants of tick-borne encephalitis severity (NW25-05-00494)

involve autoantibodies against type I interferons (IFN-I), suggesting a critical role of autoantibodies in TBE. We will evaluate the impact of autoantibodies against type I IFNs......

Virology

  • 2025 - 2028
    • •
  • 13 313 tis. Kč
    • •
  • 13 313 tis. Kč
    • •
  • MZ
Project

Role of innate immunity in the pathogenesis of type I diabetes (GAP302/10/1679)

Type 1 diabetes (T1D) is an autoimmune disease of uknown etiology.Little is is known about the role of innate immunity in disease onset and progression.Recently new publications showed the disturbances in dendritic cells (DCs) subsets in T1D...

EC - Imunologie

  • 2010 - 2014
    • •
  • 7 935 tis. Kč
    • •
  • 7 935 tis. Kč
    • •
  • GA ČR
Project

Virus sensing and interferon signaling in avian cells (GA23-07210S)

Sensing of viruses and mounting of rapid innate immune response depends on multiple cellular pathways. Key part in this process is played by RIG-I-like receptors (RLR) and by induction of interferons (IFN) by interferon reg...

Genetics and heredity (medical genetics to be 3)

  • 2023 - 2025
    • •
  • 8 083 tis. Kč
    • •
  • 8 083 tis. Kč
    • •
  • GA ČR
Project

Detection of neutralizing antibodies against interferon beta in patients with Multiple Sclerosis (MS) treated by interferon beta 1-a and beta 1-b. Clinical and pharmacoeconomical importance. (NR9445)

Annotation I: Establishing the method of detection of neutralizing antibodies against IFN-ß using cythopathic effect method. Annotation II: Inclusion of all patients treated by IFN-ß in MS centre FH Motol, detection and monitoring of product...

FH - Neurologie, neurochirurgie, neurovědy

  • 2007 - 2009
    • •
  • 3 760 tis. Kč
    • •
  • 3 590 tis. Kč
    • •
  • MZ
Project

Interferon regulatory factors in insects (GA204/99/1336)

is mediatedvia a DNA element strikingly similar to the binding sites of vertebrate interferon: (i) practically all major classes of transcriptional factors are evolutionary on the interferon system, since they also regulat...

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 603 tis. Kč
    • •
  • 603 tis. Kč
    • •
  • GA ČR
Project

Sensing of hepatitis B virus-infected hepatocytes by plasmacytoid dendritic cells (GA17-15422S)

The role of plasmacytoid dendritic cells (pDCs), a major source of interferon (IFN) alpha in human organism, in pathogenesis of hepatitis B virus (HBV) infection is not clear. We hypothesize that pDCs could be involved via production of IFN-...

EE - Mikrobiologie, virologie

  • 2017 - 2021
    • •
  • 7 608 tis. Kč
    • •
  • 6 891 tis. Kč
    • •
  • GA ČR
Project

A mouse genetic model to study the control of interferon and inflammation (GA19-16963S)

sensor. We will define the type of aberrant expression of interferon-stimulated genesVertebrates detect virus-specific nucleic acids using innate immune antiviral sensor proteins that activate interferon expression. One se...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 7 961 tis. Kč
    • •
  • 7 379 tis. Kč
    • •
  • GA ČR
Project

Use of interferon in the treatment of viral infections. (IZ2098)

9F - 9

  • 1994 - 1996
    • •
  • 560 tis. Kč
    • •
  • 810 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 7 778