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Projects

346 projects (0,14s) •

Project

Tumour virus antigens Properties, functions and interactions with host cell structures (VS96135)

The study of viral replication, functions of viral proteins in viral infection, cell regulation and transformation. The information obtained can to develoapproaches for using artificially made papovavirus capsid-li...

EA - Morfologické obory a cytologie

  • 1996 - 2000
    • •
  • 15 063 tis. Kč
    • •
  • 11 286 tis. Kč
    • •
  • MŠMT
Project

In vitro preparation of recombinant capsids for nucleic acids incorporation and internalization in the cell tissue (GP203/03/P094)

will further study binding of nucleic acids to proteins forming viral capsids. Our goal of capsid assembly and mechanism of infections can significantly contribute to better the interaction of in vitro formed viral

EE - Mikrobiologie, virologie

  • 2003 - 2005
    • •
  • 750 tis. Kč
    • •
  • 750 tis. Kč
    • •
  • GA ČR
Project

Biocompatibilization and Targeting of Nanoparticles for Diagnostic and Therapeutic Applications (LH11027)

The objective of project is i) design and preparation of a new biocompatible surfaces on nanoparticles (virus-like capsids, fluorescence nanodiamonds, magnetic nanoparticles), ii) development of synthetic methodology for their funcionalizati...

CC - Organická chemie

  • 2011 - 2014
    • •
  • 3 440 tis. Kč
    • •
  • 3 440 tis. Kč
    • •
  • MŠMT
Project

Structual antigens of papovaviruses fuctions , cellular interactions and utilisation for gene therapy purposes (GA204/96/0256)

artificially made papovavirus empty capsid-like particlaes. Th egreat advantage of these DNA transfer vehicles would be that capsid-like particles produced by self and provide as with well defined system, without unwanted viral...

EB - Genetika a molekulární biologie

  • 1996 - 1998
    • •
  • 3 048 tis. Kč
    • •
  • 2 567 tis. Kč
    • •
  • GA ČR
Project

Structural study of protein p12 from Mason-Pfizer monkey virus using NMR spectroscopy (GP203/02/P098)

, that this protein supports the assembly of immature viral capsid. The aim of this project be utilized for a design of suitable inhibitor or viral capsid assembly. The protein, p27 (capsid protein - CA), ...

CE - Biochemie

  • 2002 - 2004
    • •
  • 359 tis. Kč
    • •
  • 209 tis. Kč
    • •
  • GA ČR
Project

Interactions of flaviviral genomic and subgenomic RNA with host and viral proteins (GA18-27204S)

The project aims to characterize the virus-host interactions in the case of medically important flaviviruses – dengue virus (DENV), tick-borne encephalitis virus (TBEV), and zika virus (ZIKV). Three topics are planned to be studied: (i) the interacti...

Virology

  • 2018 - 2021
    • •
  • 12 536 tis. Kč
    • •
  • 11 669 tis. Kč
    • •
  • GA ČR
Project

Development of diagnostic components and adaptable technology of preparation of recombinant vaccines based on capsid nanostructures of the mouse polyomavirus. (TA03010700)

will be created. Fortheir preparation, artificial empty virus capsids (VLPs - virus like particles) and stabile chimeric nanostructures derived from mouse polyomavirus capsids......

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2013 - 2016
    • •
  • 18 614 tis. Kč
    • •
  • 12 089 tis. Kč
    • •
  • TA ČR
Project

Study of relationships between structure and function of phenotypically relevant mutants of Mason-Pfizer monkey virus matrix protein (GA203/03/0490)

andplays a key role in the process of capsid assembly. It is responsible for the transport of viral proteins to the site of assembly. Mutations of functional domains for assembly or for transport of capsids to the plasma m...

CE - Biochemie

  • 2003 - 2005
    • •
  • 5 104 tis. Kč
    • •
  • 3 346 tis. Kč
    • •
  • GA ČR
Project

Study of the endocytotic machinery via modification of viral-based nanoparticles (GA17-11397S)

-trap assays. Successful re-programming of viral capsids will improve endocytosis. Viral particles will be modified by series of cell penetrating peptides of therapeutically relevant delivery systems of viral and ...

EA - Morfologické obory a cytologie

  • 2017 - 2021
    • •
  • 8 082 tis. Kč
    • •
  • 7 950 tis. Kč
    • •
  • GA ČR
Project

Polyomavirus Pseudocapsids as Vectors Applications for Genetic and Immunological Therapeutic Purposes of Modified VP1 Pseudocapsids (OK 372)

DNA into cells using artefficial polyomavirus capsid-like particles. Mouse polyoma cells.Because the similarities in capsid organisation the metods developed can to the nuclus, b) to manipulate original viral structures fo...

EE - Mikrobiologie, virologie

  • 1998 - 2001
    • •
  • 2 773 tis. Kč
    • •
  • 1 853 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 346