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6 443 (0,255s) •

Project

Effect of ethanol and its principle metabolite acetaldehyde on cardiac inward rectifier potassium currents a link to atrial fibrillation related to alcohol consumption? (NT14301)

of the effect of ethanol and acetaldehyde on IK1 and IK(Ach) by whole cell patch clamp expressed in Chinese Hamster Ovary cells. Using mathematical models of rat, guinea pig......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2015
    • •
  • 3 369 tis. Kč
    • •
  • 3 229 tis. Kč
    • •
  • MZ
Project

Functional assessment of genetic variants in clinically “true” cases of idiopathic ventricular fibrillation in vitro and in silico modelling to reveal the arrhythmogenic mechanism (NU22-02-00348)

using measurements of ionic currents by the whole cell patch clamp technique, calcium imaging and/or confocal microscopy on human ionic channels expressed on a cell line and on cardiomyocytes differentiat...

Cardiac and Cardiovascular systems

  • 2022 - 2025
    • •
  • 14 750 tis. Kč
    • •
  • 14 750 tis. Kč
    • •
  • MZ
Project

Functions and membrane properties of glial cells in the rat spinal cord slices (GA309/96/0881)

technigues: the whole-cell patch-clamp will be study cell membrane currentsGlial cells play an important role in normal CNS functions as well as during and functions of glial cells (astr...

ED - Fyziologie

  • 1996 - 1998
    • •
  • 1 368 tis. Kč
    • •
  • 1 368 tis. Kč
    • •
  • GA ČR
Project

Cell volume regulation in glial cells during brain ischemia/reperfusion (GAP303/10/1338)

cells to regulate their volume, changes in cell membrane properties during ischemia or hypotonic stress will be measured by the patch-clamp technique, and the mRNA levels of relevantion channels or transporters wi...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2012
    • •
  • 3 996 tis. Kč
    • •
  • 3 996 tis. Kč
    • •
  • GA ČR
Project

Purinergic P2X receptors and their role in suprachiasmatic nuclei of hypothalamus (IAA500110702)

cells in culture and acutelly isolated or organotypic SCN slices. Patch clamp recording, single cell calcium imaging, PCR analysis, in situ hybridisation, ATP......

ED - Fyziologie

  • 2007 - 2009
    • •
  • 1 863 tis. Kč
    • •
  • 1 863 tis. Kč
    • •
  • AV ČR
Project

Clinical significance and electrophysiological evaluation of KCNQ1 gene mutation c.926C>T (p.T309I) as a possible long QT syndrome founder mutation (NV16-30571A)

analysis in wild type and mutant human IKs channels expressed in CHO cells, and mathematical simulations in a human ventricular cell model. These data will allow us......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2016 - 2020
    • •
  • 10 413 tis. Kč
    • •
  • 10 381 tis. Kč
    • •
  • MZ
Project

Electrophysiological and morfhological properties of glial cells after brain injury and transplantation (GA305/99/0655)

(patch-clamp)and immunocytochemical techniques to study the membrane properties channels and neurotransmitter receptors of reactive glial cells have not yet been transplantation and brain injury. Besides the model of nerve...

EA - Morfologické obory a cytologie

  • 1999 - 2001
    • •
  • 3 158 tis. Kč
    • •
  • 2 590 tis. Kč
    • •
  • GA ČR
Project

The role of glial cells during ischemia/reperfusion and in the course of nervous tissue regeneration. (GA305/06/1316)

/apoptosis or proliferation of the cells, and to the proliferation, migration and differentiation of endogenous neural stem cells. Using immunohistochemical and electrophysiological (patch-clamp) techniques, we wil...

FH - Neurologie, neurochirurgie, neurovědy

  • 2006 - 2008
    • •
  • 3 148 tis. Kč
    • •
  • 3 148 tis. Kč
    • •
  • GA ČR
Project

Phenotypic regulation and functional properties of glutamate receptor channels on spinal cord neurones (GA309/00/1654)

. The patch clamp technique, together with the molecular analysis of the receptor subunit mRNA expressed in the same cell using technique of a single-cell RT-PCR model of induction of an excitoxic motoneurone c...

FH - Neurologie, neurochirurgie, neurovědy

  • 2000 - 2002
    • •
  • 4 729 tis. Kč
    • •
  • 2 793 tis. Kč
    • •
  • GA ČR
Project

Membráne properties of astrocytes and the role of extracellular matrix molecules during astrogliosis in the CNS (GA305/02/1528)

and intracellular filaments on ionic channels in glial cells have not yet been studied in detail. The aim of the proposed project is to use electrophysiological (patch-clamp) and immunocytochemical techniques to study the ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2002 - 2004
    • •
  • 3 472 tis. Kč
    • •
  • 2 932 tis. Kč
    • •
  • GA ČR
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