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29 (0,107s) •

Project

Research and development of new vaccines against whooping cough (EG15_019/0005074)

Research and development of new vaccines against whooping cough...

FR - Farmakologie a lékárnická chemie

  • 2015 - 2020
    • •
  • 35 712 tis. Kč
    • •
  • 9 885 tis. Kč
    • •
  • MPO
Project

Development of an immunization preparation to protect against the causative agent of whooping cough (FW12010329)

The project's basic goal is to develop a preparation for mucosal immunization against infection by the causative agent of whooping cough, the bacterium Bordetella pertussis (whooping cough). A preparation in the fo...

Epidemiology

  • 2025 - 2027
    • •
  • 24 412 tis. Kč
    • •
  • 17 055 tis. Kč
    • •
  • TA ČR
Project

Mechanisms underlying survival of the whooping cough agent inside human phagocytes (7AMB14AR028)

The goal of this project is to develop a coordinated collaboration and the necessary synergy of the Czech and Argentinian teams that are about to apply complementary approaches to studies on intracellular survival of the whooping cough

EE - Mikrobiologie, virologie

  • 2014 - 2015
    • •
  • 320 tis. Kč
    • •
  • 320 tis. Kč
    • •
  • MŠMT
Project

Targeted drug design for bioterrorism prevention. Development of effective inhibitors of the adenylate cyclase toxin of Bordetella pertusis and Bacillus anthracis. (VG20102015046)

The aim of the proposed project of applied research is design and biological activity study of potential antibacterial drugs applicable during the act of bioterrorism. It is focused on pathogens causing whooping cough (Bordetella pe...

CC - Organická chemie

  • 2010 - 2015
    • •
  • 41 350 tis. Kč
    • •
  • 41 345 tis. Kč
    • •
  • MV
Project

Interactions of the pertussis agent with respiratory epithelia (GA18-20621S)

Under this proposal, we shall explore the mechanisms of suppression of innate immune functions of airway epithelial cells by the action of virulence factors of the whooping cough agent Bordetella pertussis. Bacterial infections and ...

Microbiology

  • 2018 - 2020
    • •
  • 8 900 tis. Kč
    • •
  • 8 798 tis. Kč
    • •
  • GA ČR
Project

Studies on mechanism of action of bacterial toxins (ME 167)

Despite an extensive use of whole cell pertussis vaccines, pertussis continues to be a medical problem. There is need for additional basic research into the structure and mechanism of action of the virulence factors of the whooping cough...

EE - Mikrobiologie, virologie

  • 1998 - 2002
    • •
  • 5 468 tis. Kč
    • •
  • 1 688 tis. Kč
    • •
  • MŠMT
Project

Immunosuppressive action of the whooping cough agent and new vaccination tools for prevention of pertussis (NV16-28126A)

Pertussis or whooping cough is a life threatening infectious disease that is now spreading in the highly vaccinated populations of the most developed countries. This is largely due to use of safe but less efficient acellular pertuss...

EE - Mikrobiologie, virologie

  • 2016 - 2019
    • •
  • 9 920 tis. Kč
    • •
  • 9 920 tis. Kč
    • •
  • MZ
Project

Mechanisms of immunomodulatory action of Bordetella pertussis virulence factors (GA13-14547S)

Whooping cough incidence is on the rise again, threatening lives of infants too young to be fully vaccinated. Rational improvement of the acellular pertussis vaccines towards induction of longer-lasting protection and higher efficac...

EE - Mikrobiologie, virologie

  • 2013 - 2017
    • •
  • 14 608 tis. Kč
    • •
  • 14 608 tis. Kč
    • •
  • GA ČR
Project

Concerted toxin action in Bordetella pertussis virulence (GX19-27630X)

Under this proposal we shall test the hypothesis that by concerted action of its protein toxins, the whooping cough agent Bordetella pertussis compromises the barrier function of airway epithelia in the initial catarrhal phase of th...

Microbiology

  • 2019 - 2023
    • •
  • 49 158 tis. Kč
    • •
  • 49 158 tis. Kč
    • •
  • GA ČR
Project

Investigation of mechanism of membrane translocation of the adenylate cyclase toxin (IAA5020611)

The adenylate cyclase toxin (ACT) is a key virulence factor of the whooping cough pathogen Bordetella pertussis. ACT exhibits several unique features, in that it penetrates into a variety of immune effector cells and paralyzes their...

EB - Genetika a molekulární biologie

  • 1996 - 1998
    • •
  • 1 826 tis. Kč
    • •
  • 1 571 tis. Kč
    • •
  • AV ČR
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