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12 (0,198s) •

Project

Cellular and molecular mechanisms of xenotransplantation reaction. Experimental model of corneal transplantation. (NR7816)

The project is focused on the study of cellular and molecular mechanisms of immune reaction after xenotransplantation and on comparison of the response to allo- and xenoantigens. Emphasis will be paied to the role of macrophages and other ce...

EC - Imunologie

  • 2004 - 2006
    • •
  • 2 054 tis. Kč
    • •
  • 2 054 tis. Kč
    • •
  • MZ
Project

Circulating microvesicles (microparticles and exosomes) for diagnosis of gynecological malignancies (NT12248)

Reliable biomarkers are needed to improve diagnosis and therapy of gynecological cancer. The aim of the project is to identify molecular characteristics of plasma circulating ovarian cancer and endometrial cancer specific microvesicles. These microve...

FK - Gynekologie a porodnictví

  • 2011 - 2015
    • •
  • 6 321 tis. Kč
    • •
  • 6 321 tis. Kč
    • •
  • MZ
Project

In vitro and in vivo function of isolated animal and human pancreatic iskets and the possibility of its modification in allogenic transplantation (ND6362)

The aim of the projekt are further development of techniques of human pancreatic islet isolation and the study of potential induction of immunologic islet tolerance with bone marrow co-transplantation. Islet function will be tested with in vitro peri...

FJ - Chirurgie včetně transplantologie

  • 2000 - 2002
    • •
  • 3 029 tis. Kč
    • •
  • 2 914 tis. Kč
    • •
  • MZ
Project

Porcine anelloviruses ? prevalence, genotypization and pathogenesis (ME08108)

for xenotransplantations and for transmission in the food chain. The goal of the project...

EE - Mikrobiologie, virologie

  • 2008 - 2012
    • •
  • 2 698 tis. Kč
    • •
  • 2 198 tis. Kč
    • •
  • MŠMT
Project

a-N-Acetylgalactosaminidase and a-galactosidase-structural and functional characterisation, use in synthesis of biologically important glycoconjugates (GA203/05/0172)

for synthesis of glycoconjugates (xenotransplantation antigen, AB aglutinogen...

CE - Biochemie

  • 2005 - 2007
    • •
  • 3 586 tis. Kč
    • •
  • 3 586 tis. Kč
    • •
  • GA ČR
Project

Center of Molecular and Cellular Immunology (1M0506)

and dendritic cells, e.g. in xenotransplantation reactions (cornea transplantatiConstruct...

EC - Imunologie

  • 2005 - 2011
    • •
  • 242 918 tis. Kč
    • •
  • 215 618 tis. Kč
    • •
  • MŠMT
Project

Inhibitors of alfa(1-3) galactosyltransferases based on the natural donor matrix (GA203/04/0355)

? -l,3-Galactosyltransferase (3GalT) transfers D-galactose from UDP-Gal to a terminal N-acetyllactosamine unit of glycoconjugates. Unlike most other mammals, humans and old world primates do not posses 3GalT activity, which is relevant for the hypera...

CC - Organická chemie

  • 2004 - 2006
    • •
  • 2 615 tis. Kč
    • •
  • 2 615 tis. Kč
    • •
  • GA ČR
Project

The diagnostic and therapeutic potential of fibroblast activation protein (FAP) in human astrocytic tumors (NT12237)

activity will utilize an orthotopic xenotransplantation model and glioma cell lines...

FD - Onkologie a hematologie

  • 2011 - 2015
    • •
  • 7 268 tis. Kč
    • •
  • 7 268 tis. Kč
    • •
  • MZ
Project

Humanized patient-derived murine xenografts for experimental therapy of hematologic malignancies and for the study of in vivo acquired drug-resistance (NV19-08-00144)

murine organs. We will strive to overcome this problem by co-xenotransplantion...

Hematology

  • 2019 - 2022
    • •
  • 16 966 tis. Kč
    • •
  • 16 966 tis. Kč
    • •
  • MZ
Project

Targeted inhibition of BCL2 family proteins in experimental therapy of diffuse large B-cell lymphoma (DLBCL) (NV15-27757A)

Diffuse large B-cell lymphoma (DLBCL) represents the most prevalent type of non-Hodgkin lymphomas (NHL) in the Western hemisphere. BCL2 and MCL1 belong to key regulators of intrinsic (mitochondrial) apoptosis. BCL2 was repeatedly associated with poor...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 6 991 tis. Kč
    • •
  • 6 991 tis. Kč
    • •
  • MZ
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