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17 (0,131s) •

Project

Epigenetic modifiers in hematopoietic malignancies (GA18-18363S)

disease in non-mammalian model organisms. Zebrafish has been proven to be valuable. There are zebrafish models of leukemia which mimic well the progression of human disease aim is to develop a new model of human leukemia in zeb...

Cell biology

  • 2018 - 2022
    • •
  • 7 437 tis. Kč
    • •
  • 6 555 tis. Kč
    • •
  • GA ČR
Project

Analysis of the craniofacial skeletal stem cell niche (GM23-06977M)

Stem cells reside in specialized microenvironments or “niches” that maintain stem cell function during the growth, maintenance, and repair of tissues. My project aims to leverage powerful genetic, imaging, and lineage tracing tools of zebrafish

Developmental biology

  • 2023 - 2023
    • •
  • 5 164 tis. Kč
    • •
  • 5 164 tis. Kč
    • •
  • GA ČR
Project

Dioscuri Centre for Stem Cell Biology and Metabolic Diseases (LV23007)

animal model for Alkaptonuria; hgd mutant zebrafish that fully recapitulates of zebrafish to test the roles of metabolism in SC maintenance. Findings from my proposed......

Cell biology

  • 2024 - 2029
    • •
  • 35 504 tis. Kč
    • •
  • 32 515 tis. Kč
    • •
  • MŠMT
Project

Red blood cells in cyprinid fish (GA16-21024S)

) and stem cell factor (SCF, or Kit ligand, Kitl). We have chosen zebrafish (Danio rerio of immortalized zebrafish erythroid cell line(s). The established cell lines and primary......

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 6 972 tis. Kč
    • •
  • 5 991 tis. Kč
    • •
  • GA ČR
Project

Cellular and molecular-genetic characterization of selected hereditary defects of erythropoiesis (NV19-07-00412)

cells, zebrafish and mouse model) to unravel the molecular-genetic mechanisms...

Hematology

  • 2019 - 2023
    • •
  • 14 136 tis. Kč
    • •
  • 14 046 tis. Kč
    • •
  • MZ
Project

Epigenetic modifications and functional properties during fish gamete aging (GA20-01251S)

-ovulatory oocyte aging as well as the post-spermiation sperm aging in zebrafish (Danio...

Reproductive biology (medical aspects to be 3)

  • 2020 - 2022
    • •
  • 7 919 tis. Kč
    • •
  • 7 778 tis. Kč
    • •
  • GA ČR
Project

In vitro and in vivo study of the consequences of disease-associated mutations in the NMDA receptor and potential rescue pharmacology (GA23-04922S)

of zebrafish (Danio rerio) with knock-out of genes grin2a or grin2b will be examined...

Neurosciences (including psychophysiology)

  • 2023 - 2025
    • •
  • 12 539 tis. Kč
    • •
  • 12 304 tis. Kč
    • •
  • GA ČR
Project

Biotechnological approaches in reproduction of freshwater fish (LH13246)

, easy maintainance, easy reproduction, short reproduction cycles, such as zebrafish...

GL - Rybářství

  • 2013 - 2014
    • •
  • 1 284 tis. Kč
    • •
  • 1 284 tis. Kč
    • •
  • MŠMT
Project

Deciphering the role of Nrf2 in the pathophysiology of phosphomannomutase 2 deficiency (GA22-18235S)

to be upregulated in zebrafish pmm2 hypomorph. It has been demonstrated that Nrf2 affects...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 6 247 tis. Kč
    • •
  • 6 247 tis. Kč
    • •
  • GA ČR
Project

Assessment of oxidative stress markers and health status in non-target aquatic organisms after selected pesticides exposure (GPP502/12/P163)

and histopathology) in zebrafish. Both pesticides will be used in embryo-larval toxicity tests...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2012 - 2014
    • •
  • 1 864 tis. Kč
    • •
  • 1 864 tis. Kč
    • •
  • GA ČR
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