Wastewater analysis as a global toxicovigilance tool for the monitoring of new psychoactive substances

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00020711%3A_____%2F25%3A10155435" target="_blank" >RIV/00020711:_____/25:10155435 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0043135425017506" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0043135425017506</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.watres.2025.124847" target="_blank" >10.1016/j.watres.2025.124847</a>

Result language

angličtina

Original language name

Wastewater analysis as a global toxicovigilance tool for the monitoring of new psychoactive substances

Original language description

New psychoactive substances are a group of synthetic or naturally occurring drugs that mimic the effects of controlled illicit drugs. With limited information around potency, effects and health risks, there is international concern around their use and thus surveillance efforts are needed for public health. This study presents a global assessment of new psychoactive substances in influent wastewater from 52 sites across 20 countries during the 2022/2023 New Year period. Using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry, 21 new psychoactive substances were detected with mitragynine, 3-methylmethcathinone, and eutylone being the most prevalent. Notably, 3,4-methylenedioxy-PV8 was identified for the first time in sites in Australia and the United States. A retrospective analysis of population normalised mass loads for 3-methylmethcathinone at European sites revealed downward trends in 2022/2023 sampling period compared to the previous years, suggesting a possible impact of regional scheduling measures. Additionally, this work demonstrates the stability of new psychoactive substances in loaded cartridges for up to four months when stored at -20 oC. These findings highlight the value of wastewater-based epidemiology for global monitoring of emerging new psychoactive substances threats and policy evaluation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10406 - Analytical chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Water Research

ISSN

—

e-ISSN

1879-2448

Volume of the periodical

289

Issue of the periodical within the volume

Part A

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

124847

UT code for WoS article

001614880800001

EID of the result in the Scopus database

2-s2.0-105020010357