Role of genetic factors in the pathogenesis of alcoholic liver disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F04%3A00001076" target="_blank" >RIV/00023001:_____/04:00001076 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Role of genetic factors in the pathogenesis of alcoholic liver disease
Original language description
Excessive alcohol intake leads to liver disease, which can range from simple steatosis to steatohepatitis, fi brosis, and/or cirrhosis. While steatosis develops in most regular drinkers, the vast majority do not develop more severe liver damage; the reasons for this are largelyunknown, but may include both environmental and genetic factors. Earlier data from retrospective epidemiological studies are confl icting, raising doubts over the relationship between alcohol consumption and the risk of liver disease. In contrast, recent prospective studies provide evidence for both a threshold effect and a dose-response relationship, suggesting that the minimum alcohol quantity that confers a measurable risk of developing alcoholic cirrhosis is 30 g ethanol perday and that the cumulative lifetime alcohol intake leading to cirrhosis is 100 kg of pure ethanol. In addition, men and women who consume more than 80 g/d of ethanol have an equal risk for cirrhosis. According to these data, less than 5%
Czech name
Úloha genetických faktorů v patogenezi alkoholického onemocnění jater
Czech description
nemoci jater, alkohol, patogeneze

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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