Prevention of contrast agent-induced renal impairment in patients with chronic renal insufficiency and heart disease by high-dose intravenous N-acetylcysteine: a pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F06%3A00001350" target="_blank" >RIV/00023001:_____/06:00001350 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Prevention of contrast agent-induced renal impairment in patients with chronic renal insufficiency and heart disease by high-dose intravenous N-acetylcysteine: a pilot study

Original language description

Contrast-induced nephropathy is a relatively common complication occurring after various procedures requiringiodisze contrast agent injection, especially in patients with pre-existing renal failure. Aim: This pilot study was designed to assess the effects of a high intravenous dose of N-acetylcysteine (NAC) on plasma creatinine concentration. Methods: Twenty patients with pre-existing renal insufficiency were given NAC at a dose of 100 mg/kg. No contrast agent was given to 10 patients (Group A), whereas10 patients received contrast at the time of coronary angiography (Group B). Changes in plasma creatinine were assessed at 3 hours and one day following NAC administration. Results: In Group B, NAC prevented creatinine increase: baseline levels were 210.98+/-77.33 ?mol/L, 200.26+/-71.94 ?mol/L (NS) after 3 hours, and 203.80+/-83.94 ?mol/L 24 hours later (NS). The following was seen in Group A patients: 201.21+/-42.28 ?mol/L, 190.31+/-42.74 ?mol/L (p<0.01), and 170.08+/-45.53 ?mol/L (p<0

Czech name

Prevence poškození ledvin kontrastní látkou u pacientů chronickou renální nedostatečností a srdečním onemocněním nitrožilní aplikací vysokých dávek N-acetylcysteinu: pilotní studie

Czech description

nefropatie indukovaná kontrastní látkou, pilotní studie

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Kardiologia Polska

ISSN

0022-9032

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

6

Country of publishing house

PL - POLAND

Number of pages

6

Pages from-to

559-564

UT code for WoS article

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EID of the result in the Scopus database

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