Long-term prevention of hypertension and end-organ damage in Ren-2 transgenic rats is achieved only with persistent but not transient AT(1 ) receptor blockade

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F07%3A00000760" target="_blank" >RIV/00023001:_____/07:00000760 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/07:1601

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Long-term prevention of hypertension and end-organ damage in Ren-2 transgenic rats is achieved only with persistent but not transient AT(1 ) receptor blockade

Original language description

The aim of this study was first to evaluate the effects of persistent or transient blockade of the angiotensin II (ANG II) receptor AT(1) on the development of hypertension and end-organ damage in hypertensive Ren-2 transgenic rats (TGR), and second to assess the potential role of AT(2) receptors in the control of blood pressure (BP) in this monogenetic model of hypertension. Male heterozygous TGR and Hannover Sprague-Dawley (HanSD) rats fed a normal salt diet were treated from day 32 of age either persistently until the end of the experiment (day 100 of age) or transiently until day 56 of age with the selective AT(1) receptor antagonist candesartan or with the combination of candesartan and the AT(2) receptor antagonist PD 123319. Persistent treatmentwith candesartan completely prevented the rise in BP, proteinuria and the increase in left ventricular weight/body weight ratio, whereas transient treatment with candesartan was effective only as long as the drug was administered. In the

Czech name

Dlouhodobé prevence hypertenze a orgánového poškození u Ren-2 transgenních potkanů je dosaženo pouze dlouhodobou, nikoliv přechodnou, blokádou AT1 receptorů

Czech description

Studie vlivu krátkodobé a dlouhodobé blokády AT1 receptorů na rozvoj hypertenze a orgánového poškození a dále potenciální úloha AT2 receptorů v regulaci krevního tlaku. Dlouhodobá léčba kandesartanem (AT1 receptorový antagonista) zabránila rozvoji hypertenze, proteinurii a srdeční hypertrofii, zatímco krátkodobé podávání této látky vykazovalo antihypertenzní účinky pouze po dobu její aplikace. AT2 receptorový antagonista (PD 123319) neměl žádný viv na sledované parametry.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

<a href="/en/project/NR8550" target="_blank" >NR8550: The role of the interaction of the AT1 and AT2 angiotensin II receptors in the ontogenesis of hypertension: a study in "Ren-2" transgenic rats</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Kidney and Blood Pressure Research

ISSN

1420-4096

e-ISSN

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Volume of the periodical

30

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

38-44

UT code for WoS article

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EID of the result in the Scopus database

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