Variants within the ghrelin gene - association with HDL-cholesterol, but not with body mass index

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F07%3A00001577" target="_blank" >RIV/00023001:_____/07:00001577 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Variants within the ghrelin gene - association with HDL-cholesterol, but not with body mass index
Original language description
Ghrelin is a hormone which influences eating habits, the amount of food ingested and the body's energy balance. We examined whether genetic variants in the ghrelin gene are associated with BMI, WHR and plasma lipid levels. We have evaluated the influenceof ghrelin polymorphisms (Arg51>Gln, Leu72>Met and Gln90>Leu) on BMI, WHR, and plasma lipid levels in 1,191 males and 1,368 females representatively selected from the Czech population. Anthropometrical and biochemical parameters were analysed in two different years. In the entire population, we have detected 4.8% of carriers of the Gln51 allele, 14.2% carriers of the Met72 allele, and 10.9% of the Leu90 allele. Frequencies did not differ between males and females and alleles were not in linkage disequilibrium. BMI or WHR were not influenced by variants in the ghrelin gene. The ghrelin variant Leu72>Met was associated with elevated levels of plasma HDL-cholesterol. Compared to Leu/ Leu homozygotes, the Met carriers had lower HDL-choles
Czech name
Varianty v genu pro ghrelin - souvislost s HDL-cholesterolem, ne však s indexem tělesné hmoty
Czech description
ghrelin, hormon, stravovací návyky, potrava, energetická bilance, BMI, koncentrace lipidů

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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