Lymphotoxin-alpha and galectin-2 SNPs are not associated with myocardial infarction in two different German populations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F07%3A00001604" target="_blank" >RIV/00023001:_____/07:00001604 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Lymphotoxin-alpha and galectin-2 SNPs are not associated with myocardial infarction in two different German populations

Original language description

Recent data provided strong evidence for the association of single nucleotide polymorphisms (SNPs) in the lymphotoxin-&#945; (LTA) and galectin-2 (LGALS2) genes with myocardial infarction (MI) in a Japanese population. For populations of other genetic background, the relevance of these polymorphisms in the pathogenesis of MI remains controversial. We aimed to define the role of LTA and LGALS2 SNPs in two GermanMI populations with markedly different ascertainment strategies. Two different MI populationswere studied. In the first population, MI patients were ascertained by a strong family history of MI (n=1214). Controls were unrelated disease-free participants of the study (n=1080). The second population included patients suffering from sporadic (nonfamilial) MI from the German KORA register (n=607). The control group consisted of participants of the WHO MONICA survey in Germany (n=1492). TaqMan assays were used to determine the genotypes of 4 SNPs in the LTA genomic region and 1

Czech name

SNP lymfotoxinu-alfa a galectinu-2 nejsou spojeny s infarktem myokrdu ve dvou různých německých populacích

Czech description

lymfotoxin-alfa; gelactin-2; infarkt myokardu; německá populace

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Molecular Medicine

ISSN

0946-2716

e-ISSN

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Volume of the periodical

85

Issue of the periodical within the volume

9

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

997-1004

UT code for WoS article

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EID of the result in the Scopus database

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