CXC and CC chemokines induced in human renal epithelial cells by inflammatroy cytokines

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F09%3A00002110" target="_blank" >RIV/00023001:_____/09:00002110 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

CXC and CC chemokines induced in human renal epithelial cells by inflammatroy cytokines

Original language description

Human renal epithelial cells might play an important role during the allograft rejection by producing chemokines in response to proinflammatory cytokines such as tumor necrosis factor (TNF)-? and interleukin (IL)-1? produced by endothelial and epithelialcells early after transplantation. The production of chemokines allows inflammatory cells to be drawn into the kidney graft and therefore plays a critical role in the pathophysiologic processes that lead to the rejection of renal transplant. In this process, two chemokine superfamilies, the CC and the CXC chemokines, are the most important. The CC chemokines target mainly monocytes and T lymphocytes, while most of the CXC chemokines attract neutrophils. We showed in our study that in vitro, in unstimulated cells, basal mRNA expression of CXC chemokines (Gro?, Gro?, Gro?, ENA-78 and GCP-2, IL-8) that attract neutrophils was detectable and expression of these genes and chemokine release were increased in TNF-?- and IL-1

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

<a href="/en/project/NR8276" target="_blank" >NR8276: The role of renal epithelium and gene polymorphisms of proinflammatory cytokines in allograft rejection</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

APMIS: Acta pathologica, microbiologica et immunologica Scandinavica

ISSN

0903-4641

e-ISSN

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Volume of the periodical

117

Issue of the periodical within the volume

7

Country of publishing house

DK - DENMARK

Number of pages

11

Pages from-to

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UT code for WoS article

000267315400001

EID of the result in the Scopus database

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