The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F10%3A00002296" target="_blank" >RIV/00023001:_____/10:00002296 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/10:00300883 RIV/00216208:11140/10:00300320

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness

Original language description

Nitric oxide belongs to the most important factors influencing structural and functional properties of vessel wall. Both genetic and environmental factors may influence its metabolism. The aim of this study was to explore whether two common polymorphismsof endothelial nitric synthase (eNOS) may, jointly with smoking, influence the stiffness of large arteries, quantified as pulse wave velocity (PWV). One hundred ninety four subjects free of manifest atherosclerotic disease or chronic pharmacotherapy were selected from population-based postMONICA study. PWV s were measured using Sphygmocor(R) device between carotic and femoral arteries (aortic PWV) and between femoral and tibialis-posterior arteries (peripheral PWV). Two common polymorphisms, T786C andG894T, were assessed. Among current smokers, homo- or heterozygous carriers of T786C mutation showed significantly higher peripheral PWV than normal genotype carriers (14.0 vs 10.7 m/sec, p<0.002); the same applied to the carriers of G894

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/NR9333" target="_blank" >NR9333: The quality of secondary and primary prevention of coronary heart disease in clinical practice- EUROASPIRE III CZ study</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

59

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

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UT code for WoS article

000282054700006

EID of the result in the Scopus database

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