Effects of human c-reactive protein on pathogenesis of features of the metabolic syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F11%3A00002448" target="_blank" >RIV/00023001:_____/11:00002448 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/11:00358902 RIV/60460709:41210/11:51087
Result on the web
<a href="http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.164350" target="_blank" >http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.164350</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.164350" target="_blank" >10.1161/HYPERTENSIONAHA.110.164350</a>
Alternative languages
Result language
angličtina
Original language name
Effects of human c-reactive protein on pathogenesis of features of the metabolic syndrome
Original language description
Major controversy exists as to whether increased C-reactive protein (CRP) contributes to individual components of the metabolic syndrome or is just a secondary response to inflammatory disease processes. We measured blood pressure and metabolic phenotypes in spontaneously hypertensive rats (SHRs) in which we transgenically expressed human CRP in the liver under control of the apolipoprotein E promoter. In transgenic SHRs, serum levels of human CRP approximated the endogenous levels of CRP normally foundin the rat. Systolic and diastolic blood pressures measured by telemetry were 10 to 15 mm Hg greater in transgenic SHRs expressing human CRP than in SHR controls (P0.01).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Hypertension
ISSN
0194-911X
e-ISSN
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Volume of the periodical
57
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
731-737
UT code for WoS article
000288434600019
EID of the result in the Scopus database
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