Belatacept-versus cyclosporine-based immunosuppression in renal transplant recipients with pre-existing diabetes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F11%3A00002516" target="_blank" >RIV/00023001:_____/11:00002516 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2215/CJN.00270111" target="_blank" >http://dx.doi.org/10.2215/CJN.00270111</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2215/CJN.00270111" target="_blank" >10.2215/CJN.00270111</a>
Alternative languages
Result language
angličtina
Original language name
Belatacept-versus cyclosporine-based immunosuppression in renal transplant recipients with pre-existing diabetes
Original language description
Background and objectives Renal transplant recipients with pre-existing diabetes (PD) have reduced graft survival and increased risk of mortality and ischemic heart disease compared with nondiabetic transplant recipients. To assess the effect of belatacept in this high-risk group, we evaluated outcomes of the subpopulation with PD from previously published BENEFIT and BENEFIT-EXT trials. Design, setting, participants, & measurements A post hoc analysis evaluated pooled data from BENEFIT (living donors or standard criteria donors) and BENEFIT-EXT (extended criteria donors). Patients were randomized to receive cyclosporine or a more intensive (MI) or less intensive (LI) belatacept regimen. Results Of 1209 intent-to-treat patients, 336 had PD. At 12 months, the belatacept LI arm demonstrated a numerically higher rate of patients surviving with a functioning graft (90.4% MI [103 of 114], 92.8% LI [90 of 971, and 80.8% cyclosporine [101 of 125]), and fewer serious adverse events than cyclos
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical journal of the American Society of Nephrology
ISSN
1555-9041
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
2696-2704
UT code for WoS article
000296821300022
EID of the result in the Scopus database
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